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[摘要]
目的 探讨注射用炎琥宁联合吸入用乙酰半胱氨酸溶液治疗肺部感染的临床疗效。方法 选择2016年1月-2017年1月西宁市第三人民医院收治的肺部感染患者153例为研究对象,随机分为对照组(76例)和治疗组(77例)。对照组雾化吸入吸入用乙酰半胱氨酸溶液,3 mL/次,2次/d。治疗组在对照组治疗基础上静脉滴注注射用炎琥宁,160 mg加入到5%葡萄糖注射液250 mL中,1次/d。两组患者均连续治疗7 d。观察两组的临床疗效,比较两组的临床肺部感染评分(CPIS)、白细胞计数、临床症状、肺部X片恢复时间和炎症因子水平。结果 治疗后,对照组和治疗组的总有效率分别为85.53%、97.40%,两组比较差异有统计学意义(P<0.05)。治疗后,两组CPIS和白细胞计数均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组体温恢复时间、咳痰消失时间、肺部X片恢复正常时间短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组超敏C反应蛋白(hs-CRP)和降钙素(PCT)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组炎症因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 注射用炎琥宁联合吸入用乙酰半胱氨酸溶液治疗肺部感染具有较好的临床疗效,可改善临床症状,降低炎症反应,安全性好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Potassium Sodium Dehydroandrographolide Succinate for injection combined with Acetylcysteine Solution for inhalation in treatment of pulmonary infection. Methods Patients (153 cases) with pulmonary infection in the Third People's Hospital of Xining from January 2016 to January 2017 were randomly divided into the control group (76 cases) and the treatment groups (77 cases). Patients in the control group were atomization inhalation administered with Acetylcysteine Solution for inhalation, 3 mL/time, twice daily. Patients in the treatment group were iv administered with Potassium Sodium Dehydroandrographolide Succinate for injection on the basis of the control group, 160 mg added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and CPIS, white blood cell count, the recovery time of clinical symptoms, lung X-ray, and the levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.53% and 97.40%, respectively, and there was difference between two groups (P<0.05). After treatment, CPIS and white blood cell count in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the recovery time of body temperature, the time of expectoration disappeared, and the recovery time of lung X-ray in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of hs-CRP and PCT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the levels of inflammatory factor indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Potassium Sodium Dehydroandrographolide Succinate for injection combined with Acetylcysteine Solution for inhalation has clinical curative effect in treatment of pulmonary infection, can improve clinical symptoms, and decrease inflammatory reactions, with good safety, which has a certain clinical application value.
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