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[摘要]
目的 探讨百合固金颗粒联合左氧氟沙星治疗社区获得性肺炎的临床疗效。方法 选取2016年1月-2016年12月在陕西省第四人民医院进行治疗的社区获得性肺炎患者78例,随机分为对照组(39例)和治疗组(39例)。对照组静脉滴注乳酸左氧氟沙星氯化钠注射液,0.5 g/次,1次/d;治疗组在对照组基础上口服百合固金颗粒,9 g/次,2次/d。两组患者均治疗7 d。评价两组患者临床疗效,同时比较治疗前后两组患者临床症状改善时间和血清学指标。结果 治疗后,对照组和治疗组临床有效率分别为79.49%和94.87%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者发热、咳痰、胸痛、气促、肺部啰音、胸片炎症吸收改善时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清超敏C反应蛋白(hs-CRP)、降钙素(PCT)、白细胞计数(WBC)、中性粒细胞比例(NEU)水平均显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组上述血清学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 采用百合固金颗粒联合左氧氟沙星治疗社区获得性肺炎患者不仅可以改善临床症状,还可降低机体炎症反应,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Baihe Gujin Granules combined with levofloxacin in treatment of community-acquired pneumonia. Methods Patients (78 cases) with community-acquired pneumonia in the Fourth People's Hospital of Shaanxi from January 2016 to December 2016 were randomly divided into control (39 cases) and treatment (39 cases) groups. Patients in the control group were iv administered with Levofloxacin Lactate and Sodium Chloride Injection, 0.5 g/time, once daily. Patients in the treatment group were po administered with Baihe Gujin Granules on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.49% and 94.87% respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of fever, expectoration, pectoralgia, anhelation, lung rale and inflammatory absorption of the chest in the treatment group after treatment was significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, the hs-CRP, PCT, WBC and NEU levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes levels in the treatment group after treatment were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Baihe Gujin Granules combined with levofloxacin in treatment of community-acquired pneumonia can improve the clinical symptoms and reduce inflammation, which has a certain clinical application value.
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