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[摘要]
目的 探讨应用丹红注射液联合多奈哌齐治疗阿尔茨海默病的临床效果。方法 选取2015年6月-2017年6月中国人民解放军白求恩国际和平医院收治的阿尔茨海默病患者106例,随机分成对照组(53例)与治疗组(53例)。对照组睡前口服盐酸多奈哌齐片,5 mg/次,1次/d。治疗组在对照组基础上静脉滴注丹红注射液,40 mL加入250 mL生理盐水,1次/d。两组均连续治疗4周。评价两组患者临床疗效,同时比较治疗前后两组患者简易精神状态量表(MMSE)评分、脑血流动力学和血清学指标。结果 治疗后,对照组临床有效率为77.4%,显著低于治疗组的92.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组MMSE评分较治疗前均显著增加(P<0.05);且治疗组比对照组升高更显著(P<0.05)。治疗后,治疗组基底动脉(BA)和双侧大脑中动脉(MCA)的平均血流速度(MFV)值均显著升高(P<0.05),搏动指数(PI)值显著下降(P<0.05);且治疗后治疗组BA和双侧MCA的MFV值和PI值比对照组改善更显著(P<0.05)。治疗后,两组血清血清磷酸化tau蛋白(P-tau)、丙二醛(MDA)、白细胞介素(IL)-8和超敏C反应蛋白(hs-CRP)水平较治疗前均显著降低(P<0.05),超氧化物歧化酶(SOD)水平均显著增加(P<0.05);且治疗组上述血清学指标比对照组改善更显著(P<0.05)。结论 应用丹红注射液联合多奈哌齐治疗阿尔茨海默病可有效改善患者脑血流状态,减轻机体氧化应激与炎症损伤,提高认知功能,延缓病情进展。
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[Abstract]
Objective To investigate the clinical effect of Danhong Injection combined with donepezil in treatment of Alzheimer disease. Methods Patients (106 cases) with Alzheimer disease in Bethune International Peace Hospital of PLA. from June 2015 to June 2017 were randomly divided into control (53 cases) and treatment (53 cases) group. Patients in the control group were po administered with Donepezil Hydrochloride Tablets, 5 mg/time, once daily. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 40 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clincial efficacies were evaluated, and the MMSE scores, the cerebral hemodynamics, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 77.4%, which was significantly lower than 92.5% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the MMSE scores in two groups were significantly increased (P<0.05), and the scores in the treatment group after treatment were significantly higher than that in the control group (P<0.05). After treatment, the BA, MFV value in two groups was significantly increased (P<0.05), but PI was significantly decreased (P<0.05). And the BA, MFV and PI value in the treatment group after treatment was significantly better than that in the control group (P<0.05). After treatment, the P-tau, MDA, IL-8 and hs-CRP levels in two groups were significantly decreased (P<0.05), but SOD levels were significantly increased (P<0.05). And the serological indexes in the treatment group after treatment was significantly better than that in the control group (P<0.05). Conclusion Danhong Injection combined with donepezil in treatment of Alzheimer disease can effectively improve the cerebral blood flow, reduce oxidative stress and inflammatory injury, improve cognitive function, and delay the disease progress.
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