目的 调查2012—2016年乌鲁木齐市第四人民医院抗抑郁药物的应用情况以及变化趋势，为抗抑郁药物的合理使用提供参考依据。方法 按照药品类型和品规对2012—2016年乌鲁木齐市第四人民医院抗抑郁药物进行统计，并对具体药物的销售金额、用药频度（DDDs）、日均费用（DDC）和药品排序比（B/A）值进行分析。结果 2012—2016年，抗抑郁药物的销售金额呈上升趋势，构成比基本稳定。门诊和住院部就诊人数以及抗抑郁症药物的销售金额均呈增长趋势。除盐酸氯米帕明片以外，其余抗抑郁药物的销售金额和DDDs均逐年上升，销售金额最高的为盐酸文拉法辛缓释胶囊，盐酸帕罗西汀片的DDDs自2013年以来一直位于第1位，其B/A值较高，其余各药物的B/A值接近于1.00。各药物的DDC值基本稳定，盐酸曲唑酮片引入本院后，其DDC值一直位于第1位。结论 乌鲁木齐市第四人民医院抗抑郁药物的临床使用合理，符合现代临床用药的发展趋势，安全、有效、副作用小的药物越来越受到欢迎。

Objective To investigate the clinical application and variation trend of antidepressants in Urumqi Fourth People's Hospital from 2012 to 2016, so as to provide a reference for the rational use of antidepressants. Methods Antidepressants were collected by the drug types and categories, and the sale amounts, defined daily dose system (DDDs), defined daily cost (DDC) and B/A were then analyzed statistically. Results From 2012 to 2016, sale amounts of antidepressants were increased year by year, and the constituent was basically stable. Also, the usage of antidepressants in outpatient and inpatient showed an increasing trend year by year. Sale amounts and DDDs of other antidepressants were gradually increased except Clomipramine Hydrochloride Tablets. Sale amounts of Venlafaxine Hydrocloride Sustained-release Capsules was the highest. DDDs of Paroxetine Hydrochloride Tablets ranked the first since 2013. And Paroxetine Hydrochloride Tablets had higher B/A value. B/A values of other antidepressants were close to 1.00. DDC of all antidepressants were stable. DDC of Paroxetine Hydrochloride Tablets ranked the first since it was introduced to the hospital. Conclusion The utilization of antidepressant drugs in Urumqi Fourth People's Hospital is reasonable. This phenomenon conforms to the development trend of clinic treatment. Safe and effective drugs with minimal side effect are becoming more and more popular.