目的 了解南京地区抗侵袭性真菌感染药物的使用情况和变化趋势，为临床合理使用药物提供参考。方法 采用回顾性分析方法对南京地区2014—2016年38家医院抗侵袭性真菌感染药物的用药金额、用药频度（DDDs）、限定日费用（DDC）及B/A进行统计分析。结果 2014—2016年，南京地区抗侵袭性真菌感染药物的用药金额逐年上升，复合年均增长率（CAGR）为11.84%，药物选择主要集中在三唑类；其中伏立康唑注射剂的销售金额、伊曲康唑口服制剂的DDDs、卡泊芬净注射剂的DDC连续3年居首位；另外抗真菌药物的使用出现新的变化；三级医院抗真菌药的用药金额占比最高；南京地区抗真菌药的选择以进口药和国产药为主。结论 南京地区抗侵袭性真菌感染药物的使用量逐年攀升，药物消费市场结构较为稳定；加强管理，促进抗侵袭性真菌感染药物合理使用。

Objective To evaluate the utilization and trend of anti-invasive fungal infection drugs in Nanjing area, and to provide a reference for clinical rational use of drugs. Methods Consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and sequence ratio (B/A) of anti-invasive fungal infection dugs in 38 hospitals of Nanjing area from 2014 to 2016 were retrospectively analyzed. Results From 2014 to 2016, consumption sum of anti-invasive fungal infection drugs in Nanjing area increased year by year with a CAGR of 11.84%. The choice of drugs mainly focused on triazoles. Consumption sum of Voriconazole Injection, DDDs of Itraconazole oral preparations, DDC of Caspofungin Injection took the first place for three years in succession. Additionally, new changes had taken place in the use of anti-invasive fungal infection drugs. Consumption sum accounted for the highest proportion in tertiary hospitals, and antifungal agents in Nanjing area was mainly imported drugs and domestic drugs. Conclusion The use of anti-invasive fungal infection drugs in Nanjing increases year by year, and the structure of drug consumption market is relatively stable. Management was strengthened to promote the rational use of anti-invasive fungal infection drugs.

常州四药医院药学科研基金资助项目（2017YX003）