目的 探讨异甘草酸镁联合左西替利嗪治疗湿疹的临床效果。方法 选取2016年1月—2017年12月天津市宁河区医院收治的142例湿疹患者，随机分为对照组和治疗组，每组各71例。对照组患者口服盐酸左西替利嗪片，5 mg/d，每晚睡前顿服。治疗组在对照组的基础上静脉滴注异甘草酸镁注射液，0.1 g加入10%葡萄糖注射液250 mL中，1次/d。两组均连续治疗2周。观察两组的临床疗效，比较两组的症状体征评分、血清细胞因子和外周血指标和皮肤病生活质量指数（DLQI）评分。结果 治疗后，对照组和治疗组的总有效率分别为74.6%、90.1%，两组比较差异有统计学意义（P<0.05）。两组临床症状、皮损面积、严重度指数（EASI）及瘙痒程度评分均较治疗前显著降低，同组治疗前后比较差异具有统计学意义（P<0.01）；且治疗后治疗组上述症状体征评分显著低于对照组，两组比较差异具有统计学意义（P<0.01）。两组血清干扰素-γ（INF-γ）、白细胞介素（IL）-4浓度均显著降低，外周血辅助性T细胞1和2比率（Th1/Th2）、CD⁴⁺和CD⁸⁺ T细胞比值（CD⁴⁺/CD⁸⁺）均显著增加，同组治疗前后比较差异具有统计学意义（P<0.05、0.01）；且治疗组上述指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。两组DLQI总分较治疗前均显著降低，同组治疗前后比较差异具有统计学意义（P<0.01）；且治疗后治疗组DLQI总分显著低于对照组，两组比较差异具有统计学意义（P<0.01）。结论 异甘草酸镁联合左西替利嗪治疗湿疹具有较好的临床疗效，可改善症状体征，抑制炎性反应，调控免疫状态，提高生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of magnesium isoglycyrrhizinate combined with levocetirizine in treatment of eczema. Methods Patients (142 cases) with eczema in Tianjin Ninghe District Hospital from January 2016 to December 2017 were divided into control and treatment groups, and each group had 71 cases. Patients in the control group were po administered with Levocetirizine Hydrochloride Tablets before going to bed, 5 mg/d. Patients in the treatment group were iv administered with Magnesium Isoglycyrrhizinate Injection, 0.1 g added into 10% glucose injection 250 mL, once daily, and they were treated for 2 week. After treatment, the clinical efficacy was evaluated, and symptoms and signs score, serum cell factor and peripheral blood index, and DLQI in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.6% and 90.1%, respectively, and there was difference between two groups (P < 0.05). Symptoms and signs score, psoriasis area, EASI, and itching degree score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.01). And the symptoms and signs score in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). INF-γ and IL-4 in two groups were significantly decreased, but Th1/Th2 and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05, 0.01). And the indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). DLQI total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.01). And the DLQI total score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.01). Conclusion Magnesium isoglycyrrhizinate combined with levocetirizine has good effect in treatment of eczema, can rapidly improve the symptoms and signs, inhibit the inflammatory reaction, regulate the immune status and improve the quality of life, which has a certain clinical application value.