目的 观察羚羊角胶囊联合硫必利治疗儿童多发性抽动症的临床疗效。方法 选取2015年9月—2017年5月在南阳医学高等专科学校第一附属医院诊治的多发性抽动症患儿142例，随机分成对照组和治疗组，每组各71例。对照组患儿口服盐酸硫必利片，起始剂量1～3片/次，逐渐增至3～6片/次，3次/d；治疗组患儿在对照组基础上口服羚羊角胶囊，1粒/次，1次/d。两组患儿均治疗12周。观察两组临床疗效，比较治疗前后两组患儿自控能力评分、血清总IgE水平、去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-HT）、γ-氨基丁酸（GABA）、谷氨酸（GLU）和天冬氨酸（ASP）水平。结果 治疗后，对照组和治疗组临床总有效率分别为87.32%和98.59%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者自控能力评分显著升高（P<0.05）；且治疗组自控能力评分明显高于对照组（P<0.05）。治疗后，两组阳性数均显著降低（P<0.05），阴性数显著升高（P<0.05）；且治疗组血清总IgE水平明显优于对照组（P<0.05）。治疗后，两组患儿血清NE和GABA水平均显著升高，血清DA、5-HT、GLU和ASP水平显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组血清单胺类神经递质和血清氨基酸神经递质水平明显优于对照组（P<0.05）。结论 羚羊角胶囊联合硫必利能够有效提高多发性抽动症患儿自控能力，改善血清总IgE水平，提高疗效和安全性。

Objective To observe the clinical efficacy of Lingyangjiao Capsules combined with tiapride in treatment of children with tourette syndrome. Methods Children (142 cases) with tourette syndrome in the First Affiliated Hospital of Nanyang Medical College from September 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 71 cases. Children in the control group were po administered with Tiapride Hydrochloride Tablets, the initial dose was 1-3 tablets/time, then gradually increased to 3-6 tablets/time, three times daily. Children in the treatment group were po administered with Lingyangjiao Capsules on the basis of the control group, 1 grain/time, once daily. Children in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the self-control ability score, IgE, NE, DA, 5-HT, GABA, GLU and ASP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 87.32% and 98.59% respectively, and there were differences between two groups (P < 0.05). After treatment, the self-control ability score in two groups was significantly increased (P < 0.05), and the score in the treatment group after treatment was significantly higher than that in the control group (P < 0.05). After treatment, the positive rate of IgE in two groups was significantly decreased, but the negative rate was significantly increased (P < 0.05). And the serum IgE in the treatment group after treatment was significantly better than that in the control group (P < 0.05). After treatment, the NE and GABA levels in two groups were significantly increased, but DA, 5-HT, GLU and ASP levels were significantly decreased (P < 0.05). And the serum monoamine and amino acids neurotransmitters in the treatment group after treatment were significantly better than those in the control group (P < 0.05). Conclusion Lingyangjiao Capsules combined with tiapride can effectively improve the children self-control ability in treatment of children with tourette syndrome, improve the serum total IgE level, the efficacy and safety.