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[摘要]
目的 研究金刚藤胶囊联合阿奇霉素胶囊治疗慢性盆腔炎的临床疗效。方法 选取2015年5月—2017年5月安阳市第三人民医院收治的慢性盆腔炎患者120例为研究对象,随机将所有患者分为对照组和治疗组,每组各60例。对照组口服阿奇霉素胶囊,1粒/次,1次/d;治疗组患者在对照组基础上口服金刚藤胶囊,4粒/次,3次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组临床症状消失时间和血清细胞因子水平。结果 治疗后,对照组和治疗组的总有效率分别为83.33%、96.67%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组体温降至正常时间、下腹痛消失时间和阴道分泌物增多消失时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)和超敏反应C蛋白(hs-CRP)水平显著下降,白细胞介素-4(IL-4)水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 金刚藤胶囊联合阿奇霉素胶囊治疗慢性盆腔炎具有较好的临床疗效,能改善临床症状,调节炎症因子水平,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the clinical effect of Jingangteng Capsules combined with Azithromycin Capsules in treatment of chronic pelvic inflammatory. Methods Patients (120 cases) with chronic pelvic inflammatory in the People No. 3 Hospital of Anyang from May 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Azithromycin Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Jingangteng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and disappearance time of clinical symptoms and serum cytokine level in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 96.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, the time of body temperature drop to normal time, the disappeared time of abdominal pain, and the increasing time of vaginal secretion in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α and hs-CRP in two groups were significantly decreased, but the levels of IL-4 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jingangteng Capsules combined with Azithromycin Capsules has clinical curative effect in treatment of chronic pelvic inflammatory, can improve clinical symptom, and regulate the levels of inflammatory factors, with good safety, which has a certain clinical application value.
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