目的 探讨四神丸联合美沙拉秦治疗溃疡性结肠炎的临床疗效。方法 选取濮阳市人民医院2016年1月—2017年6月收治的溃疡性结肠炎活动期患者184例，随机分为对照组和治疗组，每组各92例。对照组患者口服美沙拉秦缓释颗粒，1 g/次，3次/d；治疗组患者在对照组基础上口服四神丸，9 g/次，3次/d。两组患者均治疗12周。观察两组患者临床疗效，比较治疗前后两组患者血红蛋白（Hgb）、血沉（ESR）、C-反应蛋白（CRP）、前列腺素E2（PGE2）、白三烯B4（LTB4）和血小板活动因子（PAF）水平及Mayo积分和每日平均腹泻次数。结果 治疗后，对照组和治疗组临床总有效率分别为71.17%、89.13%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Hgb明显升高，ESR和CRP水平明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组患者ESR和CRP水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者PGE2、LTB4和PAF水平均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组患者PGE2和LTB4水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Mayo评分和每日腹泻次数均较治疗前明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组患者Mayo评分和每日腹泻次数明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 四神丸联合美沙拉秦可以有效改善溃疡性结肠炎患者临床症状，控制炎症，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Sishen Pills combined with mesalazine in treatment of ulcerative colitis. Methods Patients (184 cases) with ulcerative colitis in Puyang People's Hospital from January 2016 to June 2017 were randomly divided into control and treatment groups, and each group had 92 cases. Patients in the control group were po administered with Mesalazine Sustained Release Granules, 1 g/time, three times daily. Patients in the treatment group were po administered with Sishen Pills on the basis of the control group, 9 g/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, the Hgb, ESR, CRP, PGE2, LTB4 and PAF levels, the Mayo scores and frequency of diarrhea in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.17% and 89.13% respectively, and there were differences between two groups (P < 0.05). After treatment, the Hgb level in two groups was significantly increased, but ESR and CRP level was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the ESR and CRP level in the treatment group after treatment was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). After treatment, PGE2, LTB4 and PAF level in two groups was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the PGE2, LTB4 level in the treatment group after treatment was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the Mayo scores and frequency of diarrhea in two groups was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these indexes in the treatment group after treatment were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Sishen Pills combined with mesalazine can effectively improve the clinical symptoms in treatment of ulcerative colitis, and effectively control inflammation, which has a certain clinical application value.