目的 探讨祛浊胶囊联合阿托伐他汀钙治疗高脂血症的临床疗效。方法 选取2015年7月—2017年7月在石家庄市第三医院治疗的高脂血症患者108例，随机分为对照组（54例）和治疗组（54例）。对照组口服阿托伐他汀钙片，20 mg/次，1次/d。治疗组在对照组基础上口服祛浊胶囊，3 g/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，比较治疗前后两组患者血脂水平、血清一氧化氮（NO）和内皮素（ET）水平。结果 治疗后，对照组和治疗组临床有效率分别为81.48%和96.30%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者三酰甘油（TG）、胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）显著降低，高密度脂蛋白胆固醇（HDL-C）显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗组患者的血脂水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清NO水平显著升高，ET水平显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组患者NO和ET水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 祛浊胶囊联合阿托伐他汀钙治疗高脂血症效果显著，可有效降低机体血脂水平，改善机体血管内皮功能。

Objective To investigate the clinical efficacy of Quzhuo Capsules combined with atorvastatin calcium in treatment of hyperlipidemia. Methods Patients (108 cases) with hyperlipidemia in the Third Hospital of Shijiazhuang from July 2015 to July 2017 were randomly divided into control (54 cases) and treatment (54 cases). Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Quzhuo Capsules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the blood lipid levels, the serum NO and ET levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.48% and 96.30% respectively, and there were differences between two groups (P < 0.05). After treatment, the TG, TC and LDL-C levels in two groups were significantly decreased, but the HDL-C levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the blood lipid levels in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NO levels in two groups were significantly increased, but the ET levels were significantly decreased, and there were differences in the same group (P < 0.05). And the serum NO and ET levels in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Quzhuo Capsules combined with atorvastatin calcium has remarkable effect in treatment of hyperlipidemia, which can effectively reduce the blood lipid level and improve the vascular endothelial function.