目的 探讨珍菊降压片联合马来酸依那普利片治疗原发性高血压的临床疗效。方法 选取2014年6月—2017年6月在首都医科大学附属北京世纪坛医院治疗的高血压患者134例为研究对象，所有患者根据治疗方案的差别分为对照组和治疗组，每组各67例。对照组口服马来酸依那普利片，2片/次，1次/d。治疗组在对照组基础上口服珍菊降压片，1片/次，3次/d。两组患者连续治疗2个月。观察两组的临床疗效，比较两组的血压变化和血管内皮功能改善情况。结果 治疗后，对照组和治疗组的总有效率分别为74.63%、91.04%，两组比较差异有统计学意义（P<0.05）。治疗后，两组收缩压（SBP）、舒张压（DBP）均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血压明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组一氧化氮（NO）、降钙素基因相关肽（cGRP）水平显著升高，内皮素（ET）水平显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血管内皮功能指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 珍菊降压片联合马来酸依那普利片治疗原发性高血压具有较好的临床疗效，可改善血管内皮功能，安全性较好，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Zhenju Jiangya Tablets combined with Enalapril Maleate Tablets in treatment of primary hypertension. Methods Patients (134 cases) with primary hypertension in Beijing Shijitan Hospital Affiliated to Capital Medical University from June 2014 to June 2017 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Enalapril Maleate Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Zhenju Jiangya Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and blood pressure change and the improvement of vascular endothelial function in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.63% and 91.04%, respectively, and there was difference between two groups (P < 0.05). After treatment, SBP and DBP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And blood pressure indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of NO and cGRP in two groups were significantly increased, but the levels of ET in two groups were significantly decreased, and the difference was statistically significant in the same group (P <0.05). And the vascular endothelial function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Zhenju Jiangya Tablets combined with Enalapril Maleate Tablets has clinical curative effect in treatment of primary hypertension, can improve vascular endothelial function, with good safety, which has a certain clinical application value.