目的 探讨五苓胶囊联合培哚普利叔丁胺片治疗高血压的临床疗效。方法 选取2017年4月—2017年9月在宜宾市第二人民医院进行治疗的高血压病患者76例作为研究对象，采用计算机将患者随机分为对照组和治疗组，每组各38例。对照组口服培哚普利叔丁胺片，4 mg/次，1次/d。治疗组在对照组基础上口服五苓胶囊，3粒/次，3次/d。两组患者均治疗4周。观察两组的临床疗效，比较两组的血压变化情况、临床症状评分和血清细胞因子水平。结果 治疗后，对照组和治疗组的总有效率分别为81.58%、97.37%，两组比较差异有统计学意义（P<0.05）。治疗后，两组收缩压（SBP）、舒张压（DBP）均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血压变化明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组头痛、耳鸣、眩晕、心烦评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组临床症状评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清转化生长因子-β₁（TGF-β₁）、可溶性细胞间黏度分子-1（sICAM-1）、可溶性凝集素样氧化低密度脂蛋白受体1（sLOX-1）、白细胞介素-4（IL-4）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血清细胞因子明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 五苓胶囊联合培哚普利叔丁胺片治疗高血压具有较好的临床疗效，可改善临床症状，降低TGF-β₁、sICAM-1、sLOX-1、IL-4水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Wuling Capsules combined with Perindopril tert-Butylamine Tablets in treatment of hypertension. Methods Patients (76 cases) with hypertension in the Second People's Hospital of Yibin from April 2017 to September 2017 were randomly divided into control and treatment groups, and each group had 38 cases. Patients in the control group were po administered with Perindopril tert-Butylamine Tablets, 4 mg/time, once daily. Patients in the treatment group were po administered with Wuling Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and blood pressure changes, clinical symptom scores, and serum cytokine levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.58% and 97.37%, respectively, and there was difference between two groups (P < 0.05). After treatment, SBP and DBP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And blood pressure in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of headache, tinnitus, vertigo, and annoying in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P <0.05). After treatment, the levels of TGF-β₁, sICAM-1, sLOX-1, and IL-4 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And serum cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P <0.05). Conclusion Wuling Capsules combined with Perindopril tert-Butylamine Tablets has clinical curative effect in treatment of hypertension, can improve clinical symptoms, decrease the levels of TGF-β₁, sICAM-1, sLOX-1, and IL-4, which has a certain clinical application value.