目的 探讨银杏叶滴丸联合非洛地平治疗冠心病心绞痛的有效性与安全性。方法 选取滨州医学院烟台附属医院2015年12月—2017年6月收治的冠心病心绞痛患者146例，根据治疗方案的不同分成对照组（73例）和治疗组（73例）。对照组患者口服非洛地平缓释片，1片/次，1次/d。治疗组患者在对照组的基础上口服银杏叶滴丸，5丸/次，3次/d。所有患者均治疗2个月。观察两组患者临床疗效，比较治疗前后两组患者心绞痛发作频率和平均持续时间，运动耐力、血清P选择素水平、生活质量评分、心脏指标和舒张期冠状动脉血流峰值速度及不良反应情况。结果 治疗后，对照组临床总有效率为84.93%，显著低于治疗组的95.89%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者心绞痛发作频率和平均持续时间均显著降低（P<0.05）；且治疗组患者发作频率和平均持续时间明显低于对照组患者（P<0.05）。治疗后，两组患者6 min步行距离和生活质量评分均显著增加（P<0.05），血清P选择素水平显著降低（P<0.05）；且治疗后治疗组上述指标明显优于对照组（P<0.05）。治疗后，两组患者LVEF和舒张期冠状动脉血流峰值速度显著升高（P<0.05），LVEDD显著降低（P<0.05）；且治疗组患者这些指标治疗后水平明显优于对照组（P<0.05）。治疗组不良反应发生率为2.74%，明显低于对照组的13.70%，两组比较差异具有统计学意义（P<0.05）。结论 银杏叶滴丸联合非洛地平治疗冠心病心绞痛疗效显著，不良反应发生率低，具有一定的临床推广应用价值。

Objective To discuss the efficacy and safety of Yinxingye Dropping Pills combined with felodipine in treatment of angina pectoris of coronary heart disease. Methods Patients (146 cases) with angina pectoris of coronary heart disease in Yantai Affiliated Hospital of Binzhou Medical University from December 2015 to June 2017 were divided into control (73 cases) and treatment (73 cases) groups according to different treatment. Patients in the control group were po administered with Felodipine Sustained Release Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Yinxingye Dropping Pills on the basis of the control group, 5 pills/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the frequency and average duration of angina pectoris, the exercise endurance, serum P selectin level, the quality of life score, the cardiac indexes, peak velocity of coronary artery blood flow and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 84.93%, which was significantly lower than 95.89% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the frequency and average duration of angina pectoris in two groups was significantly decreased (P < 0.05). And the frequency and average duration in the treatment group after treatment was significantly lower than that in the control group (P < 0.05). After treatment, the exercise endurance and quality of life score in two groups were significantly increased (P < 0.05), but serum P selectin level was significantly decreased (P < 0.05). And the indicators in the treatment group after treatment were significantly better than those in the control group (P < 0.05). After treatment, the LVEF and peak velocity of coronary artery blood flow in two groups were significantly increased (P < 0.05), but LVEDD was significantly decreased (P < 0.05). And these indexes in the treatment group after treatment were significantly better than those in the control group (P < 0.05). During the treatment, the incidence of adverse reactions in the treatment group was 2.74%, which was significantly lower than 13.70% in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinxingye Dropping Pills combined with felodipine has significant effect in treatment of angina pectoris of coronary heart disease with low adverse reaction incidence, which has a certain clinical application value.