目的 探讨复方羊角片联合对乙酰氨基酚治疗偏头痛的临床疗效。方法 选取2016年7月—2017年7月在徐州民政医院进行诊治的偏头痛患者74例，根据用药的不同分为对照组（37例）和治疗组（37例）。对照组口服复方对乙酰氨基酚片，1片/次，若持续疼痛则1次/4～6 h，24 h内用药<4片；治疗组在对照组基础上口服复方羊角片，5片/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善情况和血清细胞因子水平。结果 治疗后，对照组临床有效率为81.08%，显著低于治疗组的97.30%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组头痛发作次数、持续时间和发作程度评分均明显下降，同组比较差异具有统计学意义（P<0.05）；且治疗组改善后临床症状显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清同型半胱氨酸（HCY）、溶血磷脂酸（LPA）、基质金属蛋白酶-9（MMP-9）水平显著降低，5羟色胺（5-HT）和β内啡肽（β-EP）水平显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗组上述血清细胞因子水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 复方羊角片联合复方对乙酰氨基酚治疗偏头痛可有效改善患者临床症状，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Compound Yangjiao Tablets combined with compound paracetamol in treatment of migraine. Methods Patients (74 cases) with migraine in Xuzhou Civil Administration Hospital from July 2016 to July 2017 were divided into control (37 cases) and treatment (37 cases) based on different treatment. Patients in the control group were po administered with Compound Paracetamol Tablets, 1 tablet/time, once every 4-6 h for the persistent pain, and less than 4 tablets in 24 h. Patients in the treatment group were po administered with Compound Yangjiao Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, the cytokine levels in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 81.08%, which was significantly lower than 97.30% in the treatment group and there were differences between two groups (P < 0.05). After treatment, the headache frequency, headache duration and degree of headache scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the clinical symptom after treatment in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the HCY, LPA, MMP-9 levels in two groups were significantly decreased, but 5-HT and β-EP levels were significantly increased, and there were differences in the same group (P < 0.05). And the cytokine levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Compound Yangjiao Tablets combined with paracetamol can obviously improve clinical symptoms in treatment of migraine, which has a certain clinical application value.