肝细胞癌的发病分子机制十分复杂，具有预后差、死亡率高的特点，并且对其有效的系统的治疗方案非常有限。近年来，随着国家对传统民族医药发展的重视，涌现出许多具有较好临床疗效的中药化合物。其中，天然产物小檗碱包含多种药理活性并且无明显毒副作用。最近的研究表明小檗碱可以通过多个方面发挥预防和降低肝细胞癌的作用，包括改善糖脂代谢，作用于线粒体有氧呼吸链，调节肠道微生态，作用于microRNAs，以及诱导p53上调和抑制分化抑制因子-1（Id-1）表达等。综述小檗碱通过改善代谢水平抗肝细胞癌的研究进展，为临床应用提供依据。

Due to the complicated molecular pathogenesis of hepatocellular carcinoma (HCC) with poor prognosis and high mortality, the option of effective systemic treatment of HCC is quite limited. In recent years, with the national attention on the development of traditional national medicine, lots of Chinese medicine compounds with good clinical effects have been found. Berberine as a natural product has multiple pharmacological activities, and has been used in traditional Chinese medicine with no significant side effects. Recent research has demonstrated that berberine has prevention and reduction activity against hepatocellular carcinoma through various pharmacological mechanisms, including the improvement of glucose, lipid metabolism, effect on mitochondrial aerobic respiration chain, regulating intestinal microecology, MicroRNAs, and inducing p53 up-regulation and suppressing Id-1 expression, etc. Research progress on anti-hepatocellular carcinoma of berberine by improving metabolism is reviewed in this paper, in order to provide the basis for clinical application.

国家自然科学基金创新研究群体项目（81621064）；国家自然科学基金青年项目（81302823）；中国医学科学院医学与健康科技创新工程项目（2016-I2M-1-011）