目的 观察百令胶囊联合别嘌醇治疗痛风性肾病的临床疗效。方法 选取2015年6月—2016年12月在天津中医药大学第一附属医院老年病科就诊的56例痛风性肾病患者，随机分为对照组和治疗组，每组各28例，对照组患者口服别嘌醇缓释胶囊，0.25 g/次，1次/d。治疗组患者在对照组的基础上口服百令胶囊，4粒/次，3次/d。两组患者均治疗8周。观察两组患者的临床疗效，比较治疗前后两组患者尿素氮（BUN）、肌酐（Cr）、血尿酸（UA）、24 h尿蛋白定量以及外周血淋巴细胞亚群水平。结果 治疗后，对照组和治疗组的总有效率分别为71.43%、89.29%，两组比较差异有统计学意义（P < 0.05）。两组BUN、Cr、UA和24 h尿蛋白水平均较治疗前降低，同组治疗前后差异有统计学意义（P < 0.05）；且治疗后治疗组上述指标均低于对照组，两组比较差异有统计学意义（P < 0.05）。治疗后，治疗组CD³⁺、CD³⁺/CD⁴⁺、CD³⁺/CD⁸⁺和CD^3-/CD¹⁶⁺⁵⁶⁺升高，CD^3-/CD¹⁹⁺和CD⁴⁺/CD⁸⁺降低，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗后治疗组外周血淋巴细胞亚群水平均优于对照组，两组比较差异有统计学意义（P < 0.05）。结论 百令胶囊联合别嘌醇治疗痛风性肾病具有较好的临床疗效，可以明显改善患者的临床症状，提高肾功能，调节细胞免疫紊乱，且安全性较好，具有一定的临床应用价值。

Objective To observe the clinical efficacy of Bailing Capsules combined with allopurinol in treatment of gouty nephropathy. Methods Patients (28 cases) with gouty nephropathy in Department of Geriatric of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 28 cases. Patients in the control group were po administered with Allopurinol Sustained-release Capsules, 0.25 g/time, once daily. Patients in the treatment group were po administered with Bailing Capsules, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and BUN, Cr, UA, and 24 h urine protein excretion, and peripheral blood lymphocytes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 89.29%, respectively, and there was difference between two groups (P < 0.05). After treatment, BUN, Cr, UA, and 24 h urine protein excretion in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, CD³⁺, CD³⁺/CD⁴⁺, CD³⁺/CD⁸⁺, and CD^3-/CD¹⁶⁺⁵⁶⁺ in the treatment group were significantly increased, while CD³⁺/CD¹⁹⁺ and CD⁴⁺/CD⁸⁺were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the peripheral blood lymphocytes indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Bailing Capsules combined with allopurinol has clinical curative effect in treatment of gouty nephropathy, can improve clinical symptoms and renal function, and regulate cellular immune disorders with good safety, which has a certain clinical application value.