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[摘要]
目的 探讨坤泰胶囊联合螺内酯片治疗多囊卵巢综合征的临床疗效。方法 选取2015年6月—2017年6月在华北理工大学附属医院就诊的多囊卵巢综合征患者120例为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组口服螺内酯片,2片/次,2次/d。治疗组在对照组基础上口服坤泰胶囊,4粒/次,3次/d。两组患者均连续治疗4周。观察两组的临床疗效,比较两组的血清激素水平、临床症状评分、排卵率、妊娠率和胰岛素抵抗情况。结果 治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P < 0.05)。治疗后,两组血清黄体生成素(LH)、睾酮(T)水平均显著降低,同组治疗前后比较差异具有统计学意义(P < 0.05);且治疗组LH、T水平均明显低于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组患者多毛评分和痤疮评分均显著升高,同组治疗前后比较差异有统计学意义(P < 0.05);且治疗组多毛评分和痤疮评分明显高于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,治疗组排卵率和妊娠率均显著高于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组稳态模型评估–胰岛素抵抗指数(HOMA-IR)和稳态模型评估–胰岛β细胞功能指数(HOMA-β)均显著下降,同组治疗前后比较差异具有统计学意义(P < 0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 坤泰胶囊联合螺内酯片治疗多囊卵巢综合征具有较好的临床疗效,能改善临床症状,调节血清激素水平,降低胰岛素抵抗,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the effects of Kuntai Capsules combined Spironolactone Tablets in treatment of polycystic ovary syndrome. Methods Women (120 cases) with polycystic ovary syndrome in the Affiliated Hospital of North China Polytechnic University from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Women in the control group were po administered with Spironolactone Tablets, 2 tablets/time, twice daily. Women in the treatment group were po administered with Kuntai Capsules on the basis of the control group, 4 grains/time, three times daily. Women in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and serum hormone levels, clinical symptom scores, ovulation rates, pregnancy rates, and insulin resistance in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of LH and T in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, hairy scores and acne scores in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the ovulation rate and pregnancy rate in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P < 0.05). After treatment, HOMA-IR and HOMA-β in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kuntai Capsules combined with Spironolactone Tablets has clinical curative effect in treatment of polycystic ovary syndrome, can improve clinical symptoms, regulate serum hormone level, and decrease insulin resistance, which has a certain clinical application value.
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