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[摘要]
目的 探讨杞菊地黄丸联合环丙沙星治疗慢性肾盂肾炎的临床效果。方法 选取日照市妇幼保健院在2015年12月—2016年12月收治的慢性肾盂肾炎患者141例,随机分成对照组(70例)和治疗组(71例)。对照组患者口服盐酸环丙沙星片,1片/1次,3次/d;治疗组在对照组的基础上口服杞菊地黄丸,8丸/次,3次/d。所有患者均经过规律治疗4周。观察两组患者临床疗效,比较治疗前后两组患者主要症状积分、肾功能指标和不良反应情况。结果 治疗后,对照组患者临床总有效率为85.71%明显低于治疗组的98.59%,停药半年内对照组和治疗组的重新感染率分别为12.86%、2.82%,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组主要症状积分明显降低(P < 0.05);且治疗组积分明显低于对照组(P < 0.05)。治疗后,两组患者的血清肌酐、血尿素氮和尿微量白蛋白水平均显著降低(P < 0.05);且治疗组患者肾功能指标水平明显低于对照组(P < 0.05)。治疗期间,治疗组患者不良反应发生率为4.23%,明显低于对照组患者的17.14%,两组比较差异具有统计学意义(P < 0.05)。结论 杞菊地黄丸联合环丙沙星治疗慢性肾盂肾炎疗效显著,可降低停药半年内重新感染率,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical effect of Qiju Dihuang Pills combined with ciprofloxacin in treatment of chronic pyelonephritis. Methods Patients (141 cases) with chronic pyelonephritis in Women and Children's Health Care Hospital of Rizhao from December 2015 to December 2016 were randomly divided into control (70 cases) and treatment (71 cases) groups. Patients in the control group were po administered with Ciprofloxacin Hydrochloride Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Qiju Dihuang Pills on the basis of the control group, 8 pills/time, three times daily. Patients in two groups were treated for 4 week. After treatment, the clinical efficacy was evaluated, and the main symptom scores, renal function indexes, adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group 85.71% was significantly lower than that in the treatment group 98.59%, the reinfection rate of six months after the therapy in the control and treatment group were 12.86%、2.82%, respectively,and there were differences between two groups (P < 0.05). After treatment, the main symptom scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum creatinine, blood urea nitrogen, and urine microalbuminuria in two groups was significantly decreased (P < 0.05), and these renal function indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). During the treatment, the incidence of adverse reactions in the treatment group was 4.23%, which was significantly lower than 17.14% in the control group, with significant difference between two groups (P < 0.05). Conclusion Qiju Dihuang Pills combined with ciprofloxacin has significant effect in treatment of chronic pyelonephritis, can reduce the reinfection rate of six months after the therapy, which has a certain clinical application value.
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