目的 探讨防芷鼻炎片联合氯雷他定治疗变应性鼻炎的临床疗效。方法 选取2016年8月—2017年6月于鄂州市中心医院耳鼻喉科就诊的变应性鼻炎患者78例，随机分为对照组（38例）和治疗组（40例）。对照组患者口服枸地氯雷他定片，1片/次，1片/d。治疗组患者在对照组的基础上，口服防芷鼻炎片，5片/次，3次/d，饭后服用，两组患者均治疗28 d。观察两组患者临床疗效，比较治疗前后两组患者鼻功能评分、肺功能和血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为73.68%和92.50%，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组鼻痒、鼻塞、喷嚏、流涕评分均明显降低，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗后治疗组上述鼻功能评分均显著低于对照组，两组比较差异有统计学意义（P < 0.05）。两组患者最大呼气流速（PEF）、1秒用力呼气容积（FEV₁）/用力肺活量（FVC）均明显升高，PEF变异率明显降低，同组治疗前后差异有统计学意义（P < 0.05）；且治疗后治疗组的肺功能指标显著优于对照组，两组比较差异有统计学意义（P < 0.05）。两组患者免疫球蛋白IgE、IgG4、白细胞介素（IL）-4、IL-5明显降低，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗后治疗组的血清学指标显著低于对照组，两组比较差异有统计学意义（P < 0.05）。结论 防芷鼻炎片联合氯雷他定治疗变应性鼻炎有较好的临床疗效，可改善患者临床症状和肺功能，并减轻机体变态反应和炎症反应，具有一定的临床应用价值。

Objective To investigate the clinical efficacy of Fangzhi Biyan Tablets combined with desloratadine in treatment of allergic rhinitis. Methods Patients (78 cases) with allergic rhinitis in Department of Otolaryngology of Ezhou Central Hospital from August 2016 to June 2017 were randomly divided into control (38 cases) and treatment (40 cases) groups. Patients in the control group were po administered with Desloratadine Citrate Disodium Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Fangzhi Biyan Tablets on the basis of the control group after mail, 5 tablets/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, and the nasal function score, pulmonary function, and serum markers in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.68% and 92.50%, respectively, and there were differences between two groups (P < 0.05). After treatment, rhinocnesmus, nasal congestion, sneezing, and runny nose scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these scores in the treatment group were lower than those in the control group, with significant difference between two groups (P < 0.05). PEF and FEV₁/FVC in two groups were significantly increased, while PEF variation was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these pulmonary function indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). IgE, IgG4, IL-4, and IL-5 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And serum markers in the treatment group were lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Fangzhi Biyan Tablets combined with desloratadine has clinical curative effect in treatment of allergic rhinitis, can improve clinical symptoms and pulmonary function, and reduce allergy and inflammation, which has a certain clinical application value.