目的 探讨固本益肠片联合柳氮磺吡啶肠溶片治疗轻中度溃疡性结肠炎的临床疗效。方法 选取2016年1月—2017年6月黄河三门峡医院收治的轻中度溃疡性结肠炎患者194例为研究对象，所有患者随机分为对照组和治疗组，每组各97例。对照组患者口服柳氮磺吡啶肠溶片，1.0 g/次，3次/d。治疗组在对照组的基础上口服固本益肠片，1.28 g/次，3次/d。两组均以10 d为1个疗程，疗程间隔5 d，连续治疗8个疗程。观察两组的临床疗效，比较两组的临床症状积分、Baron内镜评分、病变活动指数。结果 治疗后，对照组和治疗组的综合疗效总有效率分别为74.23%、92.78%，两组比较差异具有统计学意义（P < 0.05）。治疗后，对照组和治疗组的肠镜疗效总有效率分别为80.41%、94.85%，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组腹泻积分、脓血便积分、腹痛积分、里急后重积分、Baron内镜评分、病变活动指数均明显下降，同组治疗前后比较差异具有统计学意义（P < 0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P < 0.05）。结论 固本益肠片联合柳氮磺吡啶肠溶片治疗轻中度溃疡性结肠炎具有较好的临床疗效，能改善临床症状，降低病变活动指数，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Guben Yichang Tablets combined with Sulfasalazine Enteric-coated Tablets in treatment of mild and moderate ulcerative colitis. Methods Patients (194 cases) with mild and moderate ulcerative colitis in Yellow River Sanmenxia Hospital from January 2016 to June 2017 were randomly divided into control and treatment groups, and each group had 97 cases. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1.0 g/time, three times daily. Patients in the treatment group were po administered with Guben Yichang Tablets on the basis of the control group, 1.28 g/time, three times daily. With 10 d as 1 course, the course interval was 5 d, and patients in two groups were treated for 8 courses. After treatment, the clinical efficacies were evaluated, and clinical symptom scores, Baron endoscopy scores and lesion activity indexes in two groups were compared. Results After treatment, the comprehensive clinical efficacies in the control and treatment groups were 74.23% and 92.78%, respectively, and there was difference between two groups (P < 0.05). After treatment, the colonoscopy evaluation clinical efficacies in the control and treatment groups were 80.41% and 94.85%, respectively, and there was difference between two groups (P < 0.05). After treatment, diarrhea scores, pus and blood stool scores, abdominal pain scores, tenesmus scores, Baron endoscopy scores, and lesion activity indexes in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Guben Yichang Tablets combined with Sulfasalazine Enteric-coated Tablets has clinical curative effect in treatment of mild and moderate ulcerative colitis, can improve clinical symptoms, decrease lesion activity index, with good safety, which has a certain clinical application value.