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[摘要]
目的 探讨金振口服液联合孟鲁司特钠片治疗小儿支气管炎的临床疗效。方法 选取2016年7月—2017年7月焦作市妇幼保健院收治的小儿支气管炎患者106例作为研究对象,所有患儿采用随机数字表法分为对照组和治疗组,每组各53例。对照组口服孟鲁司特钠片,1片/次,1次/d。治疗组在对照组基础上口服金振口服液,1岁:5 mL/次,3次/d;2~3岁:10 mL/次,2次/d;4~7岁:10 mL/次,3次/d;8~14岁:15 mL/次,3次/d。两组患儿均治疗7 d。观察两组的临床疗效,比较两组的临床症状改善时间、血清学指标和血气指标水平。结果 治疗后,对照组和治疗组的总有效率分别为81.13%、96.23%,两组比较差异具有统计学意义(P < 0.05)。治疗后,治疗组热退时间、哮鸣音消失时间、咳嗽消失时间、喘息消失时间均短于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、可溶性髓系细胞触发受体-1(sTREM-1)和白细胞介素-13(IL-13)水平均明显降低,白细胞介素-10(IL-10)、γ-干扰素(IFN-γ)水平均明显升高,同组治疗前后比较差异具有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组氧分压(pO2)水平明显升高,二氧化碳分压(pCO2)水平明显降低,同组治疗前后比较差异具有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 金振口服液联合孟鲁司特钠片治疗小儿支气管炎具有较好的临床疗效,可改善临床症状,降低机体炎症反应,改善血气指标水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To evaluate the clinical efficacy of Jinzhen Oral Liquid combined with Montelukast Sodium Tablets in treatment of bronchitis in children. Methods Children (106 cases) with bronchitis in Jiaozuo Maternal and Child Health Care Hospital from July 2016 to July 2017 were randomly divided into control and treatment groups, and each group had 53 cases. Children in the control group were po administered with Montelukast Sodium Tablets, 1 tablet/time, once daily. Children in the treatment group were po administered with Jinzhen Oral Liquid on the basis of the control group, age 1 year:5 mL/time, three times daily, age 2 — 3 year:10 mL/time, once daily, age 4 — 7 year:10 mL/time, three times daily, age 8 — 14 year:15 mL/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and clinical symptom improvement time, serological indexes, and blood gas indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.13% and 96.23%, respectively, and there was difference between two groups (P < 0.05). After treatment, heat retreat time and the disappearance times of wheezing sound, coughing, wheezing in the treatment group were shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of TNF-α, sTREM-1 and IL-13 in two groups were significantly decreased, but the levels of IL-10 and IFN-γ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of pO2 in two groups were significantly increased, but the levels of pCO2 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinzhen Oral Liquid combined with Montelukast Sodium Tablets has clinical curative effect in treatment of bronchitis in children, can improve clinical symptoms, decrease inflammatory response, improve the levels of blood gas index, which has a certain clinical application value.
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