目的 分析2014—2016年广安门医院南区病区抗菌药物的使用情况。方法 调取广安门医院南区2014—2016年病区抗菌药物的相关用药信息，对用药频度（DDDs）、使用强度（AUD）进行统计分析。结果 病区抗菌药物给药途径以静脉注射为主，2014—2016年，抗菌药物使用DDDs减少，AUD减少，但各类品种选择结构有明显变化；β-内酰胺/β-内酰胺酶抑制剂类药物选择性增加，哌拉西林/舒巴坦选择性最强。病区使用频度最高的是硝基咪唑类；非限制级、限制级抗菌药物的DDDs和AUD下降，特殊使用级DDDs和AUD增加，尤其是美罗培南。结论 广安门医院南区病区抗菌药物连续3年使用频度及使用强度下降，说明抗菌药物管理有效，但需关注品种结构选择的变化，尤其是左奥硝唑、哌拉西林/舒巴坦、美罗培南的不合理用药问题。

Objective To investigate the utilization of antibacterial drugs for ward in South Campus of Guang'anmen Hospital from 2014 to 2016. Methods The utilization of antibacterial drugs for ward in South Campus of Guang'anmen Hospital from 2014 to 2016 was summarized retrospectively, and the varieties, defined daily doses (DDDs), antibiotics use density (AUD) were analyzed. Results Intravenous drugs were the most choice. DDDs and AUD are both decreased from 2014 to 2016, but the structure of varieties changed significantly. β-lactam/β-lactamase inhibitors was more elective, especially piperacillin-sulbactam. DDDs of nitromidazoles were the highest. DDDs and AUD of restricted and unrestricted antimicrobial drugs were decreased, but those of antibacterial agents in special use level was increased, especially meropenem. Conclusion Defined daily doses and antibiotics use density are decreased for three years in South Campus of Guang'anmen Hospital from 2014 to 2016, suggesting that the management is effective on antibacterial drug use. But the variety of structural changes of choice should be concerned, especially irrational drug use of evornidazole, piperacillin/ulbactam, and meropenem.