目的 探讨卡马西平片联合注射用鼠神经生长因子治疗耳鸣的临床疗效。方法 选取2014年7月—2016年7月中国人民解放军第三七一医院耳鼻喉科收治的耳鸣患者97例为研究对象，所有患者在随机分组的原则下分为对照组（48例）和治疗组（49例）。对照组肌肉注射注射用鼠神经生长因子，30 μg与2 mL氯化钠注射液进行混合，1次/d。治疗组在对照组基础上口服卡马西平片，1片/次，2次/d。两组患者均连续治疗3周。观察两组的临床疗效，比较两组的耳鸣致残量表（THI）评分、耳鸣响度和耳鸣残疾程度。结果 治疗后，对照组和治疗组的总有效率分别为81.25%、97.96%，两组比较差异有统计学意义（P<0.05）。治疗后，两组THI评分和耳鸣响度均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组无残疾人数均显著增多，中度残疾人数均显著减少，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 卡马西平片联合注射用鼠神经生长因子治疗耳鸣具有较好的临床疗效，可降低耳鸣响度，改善耳鸣残疾程度，安全性较好，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Carbamazepine Tablets combined with Mouse Nerve Growth Factor for injection in treatment of tinnitus. Methods Patients (97 cases) with tinnitus in Department of Otolaryngology Head & Neck Surgery of the 371st Hospital of Chinese People's Liberation Army from July 2014 to July 2016 were randomly divided into the control group (48 cases) and the treatment group (48 cases). Patients in the control group were im administered with Mouse Nerve Growth Factor for injection, 30 μg mixed with normal saline 2 mL, once daily. Patients in the treatment group were po administered with Carbamazepine Tablets on the basis of the control group, 1 tablet/time, twice daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and THI scores, tinnitus loudness, and tinnitus disability in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.25% and 97.96%, respectively, and there was difference between two groups (P < 0.05). After treatment, THI scores and tinnitus loudness in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the numbers of no disability in two groups were significantly increased, but the number of moderate disability in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Carbamazepine Tablets combined with Mouse Nerve Growth Factor for injection has clinical curative effect in treatment of tinnitus, can decrease tinnitus loudness, and improve tinnitus disability with good safety, which has a certain clinical application value.