目的 探讨金乌骨通胶囊联合依降钙素注射液治疗骨质疏松症的临床疗效。方法 选取2017年2月—2017年8月在肥城矿业中心医院进行治疗的骨质疏松症患者78例，随机分为对照组（39例）和治疗组（39例）。对照组患者肌肉注射依降钙素注射液，1 mL/次，1次/周；治疗组在对照组基础上口服金乌骨通胶囊，1.5 g/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，比较治疗前后两组患者VAS和ODI评分及骨代谢指标情况。结果 治疗后，对照组和治疗组临床总有效率分别为82.05%、97.44%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组视觉模拟评分法（VAS）和功能障碍指数（ODI）评分均显著降低，同组比较差异具有统计学意义（P<0.05）；且VAS和ODI评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清硬骨素（SOST）、骨钙素（BGP）水平均升高，β胶原特殊序列（β-CTX）、抗酒石酸酸性磷酸酶（TRACP）和N端骨钙素（N-MID）水平均降低，同组比较差异具有统计学意义（P<0.05）；且治疗组上述骨代谢指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 金乌骨通胶囊联合依降钙素注射液治疗骨质疏松症可有效改善患者临床症状和血清骨代谢指标，具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy of Jinwu Gutong Capsules combined with calcitonin in treatment of osteoporosis. Methods Patients (78 cases) with osteoporosis in Feicheng Mining Center Hospital from February 2017 to August 2017 were randomly divided into control (39 cases) and treatment (39 cases) groups. Patients in the control group were im injection administered with Elcatonin Injection, 1 mL/time, once weekly. Patients in the treatment group were po administered with Jinwu Gutong Capsules on the basis of the control group, 1.5 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the VAS and ODI scores, and bone metabolism indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.05% and 97.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, the VAS and ODI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, serum SOST and BGP levels in two groups were significantly increased, but β-CTX, TRACP, and N-MID levels were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these bone metabolism indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinwu Gutong Capsules combined with calcitonin has clinical curative effect in treatment of osteoporosis, can effectively improve the clinical symptoms and serum bone metabolism markers, which has a certain clinical application value.