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[摘要]
目的 探讨丹莪妇康煎膏联合米非司酮片治疗子宫内膜异位症的临床疗效。方法 选取2015年1月—2017年5月富平县计划生育服务站和渭南市中心医院收治的子宫内膜异位症患者140例为研究对象,按随机数字表法将患者分为对照组和治疗组,每组各70例。对照组在月经周期第1天口服米非司酮片,25 mg/次,1次/d。治疗组在对照组基础上于月经前10 d开始口服丹莪妇康煎膏,15 g/次,2次/d。两组连续服用3个月经周期。观察两组的临床疗效,比较两组的子宫内膜异位囊肿包块直径、视觉模拟评分法(VAS)评分、生活质量和激素水平。结果 治疗后,对照组和治疗组的总有效率分别为78.57%、95.71%,两组比较差异有统计学意义(P<0.05)。治疗后,两组异位囊肿包块直径和VAS评分均显著降低,生活质量积分均显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组卵泡生成激素(FSH)、黄体生成激素(LH)、睾酮(T)水平均显著降低,雌二醇(E2)水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组激素水平的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 丹莪妇康煎膏联合米非司酮片治疗子宫内膜异位症具有较好的临床疗效,可显著改善激素水平,减轻疼痛,提升生活质量,具有一定临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Dan'e Fukang Soft Extracts combined with Mifepristone Tablets in treatment of endometriosis. Methods Patients (140 cases) with endometriosis in Fuping County Family Planning Service Station and Weinan Central Hospital from January 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 70 cases. Patients in the control group were po administered with Mifepristone Tablets at the first day of menstrual cycle, 25 mg/time, once daily. Patients in the treatment group were po administered with Dan'e Fukang Soft Extracts for 10 d before menstruation on the basis of the control group, 15 g/time, twice daily. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical efficacies were evaluated, and lump diameter of endometriosis cysts, VAS score, quality of life, and hormone level in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.57% and 95.71%, respectively, and there was difference between two groups (P < 0.05). After treatment, lump diameter of endometriosis cysts and VAS score in two groups were significantly decreased, but the scores of quality of life in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of FSH, LH, and T in two groups were significantly decreased, but the levels of E2 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the hormone levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Dan'e Fukang Soft Extracts combined with Mifepristone Tablets has clinical curative effect in treatment of endometriosis, can improve ovarian function, relieve pain, and improve quality of life, which has a certain clinical application value.
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