目的 探讨克感利咽颗粒联合奥司他韦治疗儿童流行性感冒的临床疗效。方法 收集广州市妇女儿童医疗中心2015年4月—2017年5月收治的流行性感冒患儿112例，随机分为对照组和治疗组，每组各56例。对照组患儿口服磷酸奥司他韦胶囊，2 mg/kg，2次/d。治疗组在对照组基础上口服克感利咽颗粒，1袋/次，2次/d。两组患儿均连续治疗5 d。观察两组患者临床疗效，比较治疗前后两组患儿临床症候积分和症状缓解时间。结果 治疗后，对照组和治疗组临床总有效率分别为92.86%和100.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组发热、鼻塞流涕、咳嗽咯痰、头痛、恶寒和全身乏力积分均较治疗前明显降低，同组比较差异具有统计学意义（P<0.05）；且治疗组各临床症状积分均明显低于对照组，同时治疗组鼻塞流涕、咳嗽咯痰、恶寒和全身乏力的缓解时间相比对照组明显缩短，两组比较差异具有统计学意义（P<0.05）。结论 克感利咽颗粒联合奥司他韦治疗儿童流行性感冒可显著缩短临床症状缓解时间，提高临床治疗效果。

objective To study the curative effect of Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza. Methods Children (112 cases) with influenza in Guangzhou Women and Children's Medical Center from April 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 56 cases. Children in the control group were po administered with Oseltamivir Phosphate Capsules, 2 mg/kg, twice daily. Children in the treatment group were po administered with Kegan Liyan Granules on the basis of the control group, 1 bag/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms scores and symptom alleviative time in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 92.86% and 100.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, the fever, stuffy running nose, cough and expectoration, headache, aversion to cold and malaise scores in two groups were significantly decreased, and there were differences in the same group (P < 0.05). And the clinical symptoms scores in the treatment group were significantly lower than those in the control group, and the alleviative time of stuffy running nose, cough and expectoration, aversion to cold and malaise in the treatment group was significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza can significantly shorten the time of relief symptom and improve the clinical efficacy.