[关键词]
[摘要]
柴胡皂苷是传统中药柴胡的主要生物活性成分,具有抗肿瘤、抗氧化损伤、抗纤维化和免疫调节等作用。目前已有大量文献报道了有关柴胡皂苷抗肿瘤作用的研究成果,其抗肿瘤的作用机制主要包括诱导肿瘤细胞凋亡与分化、抑制肿瘤血管生长、抑制肿瘤侵袭转移、逆转肿瘤细胞多药耐药、免疫调节作用、联合放化疗减毒增敏效应、调控肿瘤细胞自噬以及抑制环氧合酶等,其中诱导肿瘤细胞凋亡是通过抑制肿瘤细胞增殖、影响肿瘤基因表达、抑制肿瘤细胞分裂以及细胞毒作用实现的。通过查阅国内外研究文献,对柴胡皂苷的抗肿瘤作用进行综述。
[Key word]
[Abstract]
Saikosaponins are the main bioactive ingredients of traditional Chinese medicine Radix Bupleuri, and have the effects of antitumor, anti-oxidative damage, anti-fibrosis, and immune regulation. At present, a large number of literatures have reported the research results of the antitumor effect of saikosaponin, and the mechanism of action mainly includes induction of apoptosis and differentiation of tumor cells, inhibition of tumor vascular growth, inhibition of tumor invasion and metastasis, reversal of multidrug resistance in tumor cells, immunomodulatory effect, hypersensitivity and sensitization effect of combined radiotherapy and chemotherapy, regulation of autophagy in tumor cells, and inhibition of cyclooxygenase, etc. Apoptosis is induced by inhibiting tumor cell proliferation, affecting tumor gene expression, inhibiting cell division, and cytotoxicity. This study gives a brief review on the antitumor effect of saikosaponins by consulting references at home and abroad.
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