目的 探讨银杏蜜环口服溶液联合甲钴胺注射液治疗突发性耳聋的临床疗效。方法 选取2016年8月—2017年8月在河北省沧州中西医结合医院进行治疗的突发性耳聋患者86例为研究对象，根据用药的差别将入组患者随机分为对照组和治疗组，每组各43例。对照组静脉滴注甲钴胺注射液，1 mg加入到0.9%氯化钠注射液100 mL中，1次/d。治疗组在对照组基础上口服银杏蜜环口服溶液，10 mL/次，3次/d。两组患者均治疗2周。观察两组的临床疗效，比较两组的临床症状改善时间、血液流变学和血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为81.40%、97.67%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组耳鸣、耳闷和眩晕恢复时间均短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血浆黏度（PV）、全血黏度高切（HS）、红细胞聚集指数（EAI）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清可溶性血管细胞间黏附分子-1（sVCAM-1）、过氧化脂质（LPO）、血栓素B₂（TXB₂）水平均明显降低，降钙素基因相关肽（CGRP）、超氧化物歧化酶（SOD）水平均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 银杏蜜环口服溶液联合甲钴胺注射液治疗突发性耳聋具有较好的临床疗效，可改善临床症状，调节血液流变学指标，修复血管内皮损伤，改善机体氧化应激水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Ginkgo Leaf Extract and Armillariella Mellea Powders Oral Solution combined with Mecobalamin Injection in treatment of sudden deafness. Methods Patients (86 cases) with sudden deafness in Cangzhou Hospital of Integrated Traditional and Western Medicine of Hebei from August 2016 to August 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 43 cases. Patients in the control group were iv administered with Mecobalamin Injection, 1 mg added into normal saline 100 mL, once daily. Patients in the treatment group were po administered with Ginkgo Leaf Extract and Armillariella Mellea Powders Oral Solution on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom improvement time, hemorheological indexes, and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 97.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, the recovery time of tinnitus, ear muffle, and vertigo in the treatment group were shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the PV, HS, and EAI in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of sVCAM-1, LPO, and TXB₂ in two groups were significantly decreased, but the levels of CGRP and SOD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Ginkgo Leaf Extract and Armillariella Mellea Powders Oral Solution combined with Mecobalamin Injection has clinical curative effect in treatment of sudden deafness, can improve clinical symptoms, regulate hemorheological indexes, repair vascular endothelial injury, and improve the level of oxidative stress, which has a certain clinical application value.