目的 探讨红金消结胶囊联合来曲唑片治疗子宫肌瘤的临床疗效。方法 选取2016年1月—2017年1月在新乡市第一人民医院进行诊治的子宫肌瘤患者54例临床资料进行回顾性分析，根据用药差别将入组患者分为对照组和治疗组，每组各27例。对照组在月经结束后第1天口服来曲唑片，2.5 mg/次，1次/d。治疗组在对照组基础上口服红金消结胶囊，1.2 g/次，3次/d。两组均以1个月经周期为1个疗程，治疗3个疗程。观察两组的临床疗效，比较两组的子宫体积、子宫肌瘤体积、血清性激素和细胞因子水平。结果 治疗后，对照组和治疗组的总有效率分别为77.78%、96.30%，两组比较差异有统计学意义（P<0.05）。治疗后，两组子宫肌瘤体积和子宫体积均显著缩小，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显小于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清雌二醇（E₂）、孕酮（P）、促卵泡成熟激素（FSH）、黄体生成素（LH）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清血管生成素-2（Ang-2）、血管内皮生长因子（VEGF）、基质金属蛋白酶-2（MMP-2）、人附睾蛋白4（HE4）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 红金消结胶囊联合来曲唑片治疗子宫肌瘤具有较好的临床疗效，可缩小子宫肌瘤体积，改善E₂、P、LH、FSH、Ang-2、VEGF、MMP-2、HE4水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Hongjinxiaojie Capsules combined with Letrozole Tablets in treatment of uterine fibroids. Methods Patients (54 cases) with uterine fibroids in Xinxiang First People's Hospital from January 2016 to January 2017 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 27 cases. Patients in the control group were po administered with Letrozole Tablets at the first day after the end of menstruation, 2.5 mg/time, once daily. Patients in the treatment group were po administered with Hongjinxiaojie Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 3 courses, and 1 menstrual cycle for 1 course. After treatment, the clinical efficacies were evaluated, and uterine volume, uterine fibroids volume, sex hormone level, and cytokine level in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 96.30%, respectively, and there was difference between two groups (P < 0.05). After treatment, uterine volume and uterine fibroids volume in two groups were significantly shrunk, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly narrower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of E₂, P, FSH, and LH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of Ang-2, VEGF, MMP-2, and HE4 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Hongjinxiaojie Capsules combined with Letrozole Tablets has clinical curative effect in treatment of uterine fibroids, can reduce the size of uterine fibroids, improve E₂, P, LH, FSH, Ang-2, VEGF, MMP-2, and HE4, which has a certain clinical application value.