目的 探讨芪苈强心胶囊联合奥普力农注射液治疗慢性充血性心力衰竭的临床效果。方法 选取2015年7月—2017年6月在濮阳市安阳地区医院就诊的慢性充血性心力衰竭患者148例，随机分为对照组（74例）与治疗组（74例）。对照组静脉滴注盐酸奥普力农注射液，首先以10 μg/kg滴注10 min，再以0.2 μg/kg静脉泵注250 min。治疗组在对照组基础上口服芪苈强心胶囊，4粒/次，3次/d。两组患者连续治疗1周。观察两组患者临床疗效，比较治疗前后两组患者心功能、脂联素（APN）、抗利尿激素（ADH）和氨基末端脑钠肽前体（NT-pro BNP）水平以及6 min步行试验（6 MWT）变化。结果 治疗后，对照组和治疗组临床总有效率分别为82.43%和93.24%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者左心室收缩末期容积（LVESV）均明显降低，心输出量（CO）、心脏指数（CI）和左心室射血分数（LVEF）明显增加，同组比较差异具有统计学意义（P<0.05）；且治疗组LVESV、CO、CI和LVEF改善后水平明显优于对照组（P<0.05）。治疗后，两组患者血清APN、ADH和NT-pro BNP水平均显著下降（P<0.05）；且治疗组患者血清APN、ADH和NT-pro BNP水平降低的更显著（P<0.05）。治疗后，两组患者6 MWT均比治疗前显著增加（P<0.05）；且治疗组6 MWT大于对照组（P<0.05）。结论 芪苈强心胶囊联合奥普力农注射液治疗慢性充血性心力衰竭可显著提高患者的心功能，降低血清NT-pro BNP、APN和ADH水平，疗效确切。

Objective To evaluate the clinical effect of Qili Qiangxin Capsules combined with olprinone in treatment of chronic congestive heart failure. Methods Patients (148 cases) with chronic congestive heart failure in Puyang Anyang District Hospital from July 2015 to June 2017 were randomly divided into control (74 cases) and treatment (74 cases) groups. Patients in the control group were iv administered with Olprinone Hydrochloride Injection, firstly dripped at the speed of 10 μg/kg for 10 min, then intravenous pumped at the speed of 0.2 μg/kg for 250 min. Patients in the treatment group were po administered with Qili Qiangxin Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the changes of cardiac function, APN, ADH and NT-pro BNP levels, and 6 MWT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.43% and 93.24%, respectively, and there were differences between two groups (P < 0.05). After treatment, LVESV levels in two groups were significantly decreased, but CO, CI and LVEF levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the LVESV, CO, CI and LVEF levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, APN, ADH and NT-pro BNP levels in two groups were significantly decreased (P < 0.05). And the APN, ADH and NT-pro BNP levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the 6 MWT in two groups was significantly increased (P < 0.05). And the increase distance of 6 MWT in the treatment group was significantly longer than that in the control group (P < 0.05).Conclusion Qili Qiangxin Capsules combined with olprinone can significantly improve the cardiac function in treatment of chronic congestive heart failure, and reduce the serum NT-pro BNP, APN and ADH levels, which has exact curative effect.