目的 探讨采用血府逐瘀胶囊联合丁苯酞治疗缺血性脑血管的临床效果。方法 选取秦皇岛市中医医院在2016年3月—2017年3月收治的缺血性脑血管疾病患者161例，随机分成对照组（80例）和治疗组（81例）。对照组患者静脉滴注丁苯酞氯化钠注射液，100 mL/次，2次/d；治疗组患者在对照组的基础上口服血府逐瘀胶囊，6粒/次，2次/d。所有患者均经过规律治疗15 d。观察两组患者临床疗效，比较治疗前后两组患者临床评分、基质金属蛋白酶-9（MMP-9）、脑血容量（CBV）和脑血流量（CBF）水平以及不良反应情况。结果 治疗后，对照组和治疗组的临床总有效率分别为86.25%和96.30%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者神经功能缺损评分（NIHSS）评分明显降低，简易智能精神状态检查量表（MMSE）和日常生活活动能力量表（ADL）评分显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗组各临床评分显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者MMP-9水平显著降低，CBV和CBF水平显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗组MMP-9、CBV和CBF水平改善情况明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，治疗组不良反应发生率为2.47%，显著低于对照组患者的12.50%，两组比较差异具有统计学意义（P<0.05）。结论 血府逐瘀胶囊联合丁苯酞治疗缺血性脑血管疾病疗效显著，安全性高，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Xuefu Zhuyu Capsules combined with butyphthalide in treatment of ischemic cerebrovascular diseases. Methods Patients (161 cases) with ischemic cerebrovascular diseases in Qinhuangdao Hospital of TCM from March 2016 to March 2017 were randomly divided into control (80 cases) and treatment (81 cases) groups. Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily. Patients in the treatment group were po administered with Xuefu Zhuyu Capsules on the basis of the control group, 6 grains/times, twice daily. Patients in two groups were treated for 15 d. After treatment, the clinical efficacy were evaluated, the clinical scores, MMP-9, CBV and CBF levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 86.25% and 96.30%, respectively, and there were differences between two groups (P < 0.05). After treatment, the NIHSS scores in two groups were significantly decreased, but MMSE and ADL scores were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the clinical scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, MMP-9 levels in two groups were significantly decreased, but CBV and CBF levels were significantly increased, and there were differences in the same group (P < 0.05). And the improvement of MMP-9, CBV and CBF levels in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). During the treatment, the incidence of adverse reactions in the treatment group was 2.47%, which was significantly lower than 12.50% in the control treatment group, with significant difference between two groups (P < 0.05). Conclusion Xuefu Zhuyu Capsules combined with butyphthalide has significant effect in treatment of ischemic cerebrovascular diseases with high safety, which has a certain clinical application value.