目的 探讨参麦注射液致药品不良反应的特点及相关因素，为临床合理用药提供参考。方法 检索2007年1月-2017年6月中国学术期刊（网络版）、万方数字化期刊全文库、中文科技期刊全文数据库（维普）及PubMed数据库收录的全部中医药期刊，收集报道参麦注射液致不良反应的文献进行统计和分析。结果 参麦注射液引发的不良反应女性明显多于男性，年龄多集中在41~60岁，在用药10 min以内出现不良反应的例数最多，占45.76%，以心血管和皮肤及附件损害较为多见，所占构成比分别为30.69%、15.93%。结论 临床应加强参麦注射液的合理使用，尽量避免或减少其所致不良反应的发生。

Objective To investigate the characteristics and relative factors of adverse drug reaction (ADR) induced by Shenmai Injection, and to provide references for clinical rational drug use. Methods Chinese Academic Journal (online), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and PubMed databases were retrieved from January 2007 to June 2017, and the documents of ADR induced by Shenmai Injection were analyzed and discussed. Results Women with ADR induced by Shenmai Injection were more than men, and more were focused on 41-60 years old. The most cases (45.76%) occured within the medication 10 min. Organs/systems involved by ADR mainly were cardiovascular, skin and accessory injury, accounting for 30.69% and 15.93%, respectively. Conclusion More attention should be paid on the rational use of Shenmai Injection to reduce or avoid the occurrence of adverse reactions.

国家科技支撑计划项目（2007BAI47B00）