目的 了解2012-2016年淄博市中心医院静脉用药调配中心（PIVAS）抗肿瘤药物的不合理使用情况，为临床合理用药提供参考。方法 选取2012年11月-2016年12月淄博市中心医院PIVAS记录的不合理医嘱3 655张，对不合理用药情况进行回顾性分析。结果 2012年11月-2016年12月，抗肿瘤药物的不合理医嘱共计909条，其中不合理原因主要分为溶媒选择不合理、溶媒用量不合理、给药剂量不合理、给药途径不合理和其他5种类型；以溶媒选择不合理为主，占不合理医嘱的58.30%；注射用卡铂和注射用奥沙利铂的溶媒选择不合理医嘱的构成比分别为12.26%、10.57%；注射用吉西他滨和注射用奈达铂的溶媒用量不合理医嘱的构成比分别为17.26%、16.37%；艾迪注射液、鸦胆子油乳注射液和复方苦参注射液给药剂量不合理医嘱的构成比分别为31.25%、27.68%、24.11%。结论 淄博市中心医院PIVAS对抗肿瘤药物审核及干预效果显著，有效减少不合理用药，促进临床合理用药。

Objective To investigate the unreasonable use of antitumor drugs in Pharmacy Intravenous Admixture Service (PIVAS) in Central Hospital of Zibo from 2012 to 2016, and to provide reference for rational drug use. Methods Irrational medication orders (3 655 cases) in PIVAS in Central Hospital of Zibo from November 2012 to December 2016 were checked, and the irrational medication orders were evaluated and analyzed. Results 909 Cases of antitumor drug orders were irrational from November 2012 to December 2016, which mainly included unreasonable solvent selection, inappropriate solvent dosage, improper administration dosage, irrational administration route, and others. Most was unreasonable solvent selection, accounting for 58.30%, in which the ratio of Carboplatin for injection and Oxaliplatin for injection was 12.26% and 10.57%, respectively. In terms of inappropriate solvent dosage, the ratio of Gemcitabine Hydrochloride for injection and Nedaplatin for injection was 17.26% and 16.37%, respectively. In terms of improper administration dosage, the ratio of Aidi Injection, Yadanzi Oil Emulsion Injection, and Compound Kushen Injection was 31.25%, 27.68%, and 24.11%, respectively. Conclusion The auditing and intervention on the use of antitumor drugs in PIVAS in Central Hospital of Zibo has good effect, and can reduce irrational use of drugs, and promote rational use of drugs in clinic.