目的 探讨小金片联合甲泼尼龙片治疗亚急性甲状腺炎的临床疗效。方法 选取2015年4月-2017年4月在广州市番禺区中医院进行诊治的亚急性甲状腺炎患者312例，根据用药的差别分为对照组（156例）和治疗组（156例）。对照组口服甲泼尼龙片，初始剂量24 mg/d，2周后16 mg/d，4周后8 mg/d，6周后4 mg/d。治疗组在对照组的基础上口服小金片，0.72 g/次，2次/d。两组患者均治疗8周。观察两组患者临床疗效，比较治疗前后两组患者临床症状和血清学指标改善情况。结果 治疗后，对照组的临床有效率为82.05%，显著低于治疗组的92.31%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组咽痛、甲状腺疼痛和甲状腺肿块消失时间以及退热时间均明显短于对照组患者，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清C反应蛋白（CRP）、血沉、甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TPOAb）和促甲状腺激素受体抗体（TRAb）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组患者上述血清学指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小金片联合甲泼尼龙片治疗亚急性甲状腺炎可有效改善患者临床症状和炎症状态，有利于恢复受损的甲状腺功能，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Xiaojin Tablets combined with methylprednisolone in treatment of subacute thyroiditis. Methods Patients (312 cases) with subacute thyroiditis in Guangzhou Panyu District Hospital of Traditional Chinese Medicine from April 2015 to April 2017 were divided into control (156 cases) and treatment (156 cases) groups according to different treatments. Patients in the control group were po administered with Methylprednisolone Tablets, the initial dose was 24 mg/d, and 16 mg/d after 2 weeks, 8 mg/d after 4 weeks, 4 mg/d after 6 weeks. Patients in the treatment group were po administered with Xiaojin Tablets on the basis of the control group, 0.72 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and serological indexes in two groups before and after treatment was compared. Results After treatment, clinical efficacy in the control group was 82.05%, which were significantly lower than 92.31% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of pharyngodynia, thyroid pain, thyroid nodule and fever in the treatment group were significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the CRP, ESR, TGAb, TPOAb and TRAb levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes after treatment in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiaojin Tablets combined with methylprednisolone can effectively improve the clinical symptoms and inflammatory state in treatment of subacute thyroiditis, which is conducive to the recovery of impaired thyroid function and has a certain clinical application value.