目的 探讨血必净联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床疗效。方法 收集2015年2月-2017年2月在安阳市人民医院进行治疗的深度烧伤患者78例，根据用药的差别分为对照组（39例）和治疗组（39例）。对照组于患处涂抹重组牛碱性成纤维细胞生长因子凝胶，每次300 IU/cm²，2次/d。治疗组在对照组的基础上静脉滴注血必净注射液，100 mL加入生理盐水100 mL，1次/d。两组患者均经过2周治疗。观察两组患者临床疗效，比较治疗前后两组患者细菌清除率、血清学指标和创面愈合时间。结果 治疗后，对照组和治疗组的临床总有效率分别为79.49%、94.87%，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组的细菌清除率为54.84%，明显低于治疗组的84.38%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清IL-1β、IL-6和肿瘤坏死因子-α（TNF-α）水平均显著降低，IL-4和IL-10水平均增高，同组比较差异具有统计学意义（P<0.05）；且治疗组血清学指标比对照组改善更明显，两组比较差异具有统计学意义（P<0.05）。治疗组创面愈合时间明显短于对照组，两组比较差异具有统计学意义（P<0.05）。结论 血必净联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面可有效降低机体炎症反应，促进创面愈合，具有一定的临床推广应用价值。

Objective To investigate the efficacy of Xuebijing Injection combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in treatment of residue wound surface of deep burn. Methods Patients (78 cases) with residue wound surface of deep burn in Anyang People's Hospital from February 2015 to February 2017 were divided into control (39 cases) and treatment (39 cases) groups according to different treatments. Patients in the control group applied Recombinant Bovine Basic Fibroblast Growth Factor Gel on the residue wound surface, 300 IU/cm² for each time, twice daily. Patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group, 100 mL added into normal saline 100 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the bacterial clearance rate, serological indexes and the time of wound healing in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.49% and 94.87%, respectively, and there were differences between two groups (P<0.05). After treatment, the bacterial clearance rate in the control group was 54.84%, which were significantly lower than 84.38% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the IL-1β, IL-6 and TNF-α levels in two groups were significantly decreased, but IL-4 and IL-10 levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The time of wound healing in the treatment was significantly earlier than that in the control group, with significant difference between two groups (P<0.05). Conclusion Xuebijing Injection combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel can effectively reduce the inflammatory reaction and promote wound healing in treatment of residue wound surface of deep burn, which has a certain clinical application value.