目的 探讨胆清胶囊联合熊去氧胆酸胶囊治疗胆囊结石的临床效果。方法 选择2016年3月-2017年8月中国医科大学附属盛京医院收治的126例胆囊结石患者，随机分为对照组和治疗组，每组各63例。对照组口服熊去氧胆酸胶囊，250 mg/次，1次/d。治疗组在对照组基础上口服胆清胶囊，3~5粒/次，3次/d。两组均连续治疗2个月。观察两组的临床疗效，比较两组治疗前后中医症状积分、结石直径、VAS评分的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为76.19%、93.65%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组右上腹疼痛评分、不思饮食评分、恶心呕吐评分、口苦咽干评分、总评分均显著降低，同组治疗前后差异有统计学意义（P<0.05）；治疗后，治疗组右上腹疼痛评分、不思饮食评分、恶心呕吐评分、口苦咽干评分、总评分均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组结石直径均明显缩小，VAS评分均明显降低，同组治疗前后差异有统计学意义（P<0.05）；治疗后，治疗组结石直径、VAS评分均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 胆清胶囊联合熊去氧胆酸胶囊治疗胆囊结石具有较好的临床疗效，可显著降低中医症状积分，缩小胆囊结石体积，缓解腹痛，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Danqing Capsules combined with Ursodeoxycholic Acid Capsules in treatment of cholecystolithiasis. Methods Patients (126 cases) with cholecystolithiasis in Shengjing Hospital of China Medical University from March 2016 to August 2017 were randomly divided into control (63 cases) and treatment (63 cases) groups. Patients in the control group were po administered with Ursodeoxycholic Acid Capsules, 250 mg/time, once daily. Patients in the treatment group were po administered with Danqing Capsules on the basis of the control group, 3 -5 capsules/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the changes of TCM symptom scores, calculi diameter, VAS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 76.19%, 93.65%, respectively, and there was difference between two groups (P<0.05). After treatment, pain score on the right upper abdomen, the diet score, the nausea and vomiting score, the dry pharynx score and the total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, pain score on the right upper abdomen, the diet score, the nausea and vomiting score, the dry pharynx score and the total score in treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). After treatment, the calculi diameter and VAS score were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the calculi diameter and VAS score were lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Danqing Capsules combined with Ursodeoxycholic Acid Capsules has clinical curative effect in treatment of cholecystolithiasis, and can significantly reduce the TCM symptoms scores and the volume of gallbladder stones, also can relieve abdominal pain, which has a certain clinical application value.