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[摘要]
目的 探究鼻渊糖浆联合氯雷他定治疗变应性鼻炎的临床效果。方法 选取2015年1月-2016年12月在江苏省金湖县人民医院接受治疗的变应性鼻炎患者96例,随机分为对照组和治疗组,每组各48例。对照组患者口服氯雷他定分散片,10 mg/次,1次/d;治疗组患者在对照组的基础上口服鼻渊糖浆,15 mL/次,3次/d。两组患者均治疗3个月。观察两组患者临床效果,比较两组患者治疗前后呼吸功能水平和症状体征评分以及复发情况。结果 治疗后,对照组和治疗组临床总有效率分别为68.75%和89.58%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者最大呼气流速(PEF)水平显著提高,PEF变异率和症状体征评分显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组患者上述评价指标明显好于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者复发和反复情况远低于对照组患者,两组比较差异具有统计学意义(P<0.05)。结论 鼻渊糖浆联合氯雷他定在迅速消除变应性鼻炎病症体征和减少病情反复方面效果显著,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical efficacy of Biyuan Syrup combined with loratadine in treatment of allergic rhinitis. Method Patients (96 cases) with allergic rhinitis in Jinhu County People's Hospital from January 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Loratadine Dispersible Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Biyuan Syrup on the basis of the control group, 15 mL/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and respiratory function, symptom and sign scores, and recurrence in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 68.75% and 89.58%, respectively, and there were differences between two groups (P<0.05). After treatment, PEF levels in two groups were significantly increased, but PEF variation rate, and symptom and sign scores were significantly decreased, and there were differences in the same group (P<0.05). And these evaluation indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the recurrence rate in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). Conclusion Biyuan Syrup combined with loratadine has significant effect on eliminating the symptoms of allergic rhinitis and reducing the recurrence in treatment of allergic rhinitis, which has a certain clinical application value.
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