目的 探讨乳酸菌素片联合马来酸曲美布汀片治疗混合型肠易激综合征的临床疗效。方法 选取2014年6月-2016年12月在漯河市中心医院进行治疗的混合型肠易激综合征患者80例为研究对象，根据用药的差别将入组患者分为对照组和治疗组，每组各40例。对照组口服马来酸曲美布汀片，0.1 g/次，3次/d。治疗组在对照组基础上口服乳酸菌素片，2.4 g/次，3次/d。两组患者均连续治疗4周。观察两组的临床疗效，比较两组的临床症状评分和血清胃肠激素水平。结果 治疗后，对照组和治疗组的总有效率分别为82.50%、97.50%，两组比较差异有统计学意义（P<0.05）。治疗后，两组腹胀、腹痛、腹泻、便秘评分和总评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清血管活性肠肽（VIP）、胃动素（MTL）水平均显著降低，P物质（SP）水平均显著增加，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 乳酸菌素片联合马来酸曲美布汀片治疗混合型肠易激综合征具有较好的临床疗效，可改善临床症状，调节血清胃肠激素水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Lacidophilin Tablets combined with Trimebutine Maleate Tablets in treatment of mixed type of irritable bowel syndrome. Methods Patients (80 cases) with mixed type of irritable bowel syndrome in Luohe Central Hospital from June 2014 to December 2016 were enrolled. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Trimebutine Maleate Tablets, 0.1 g/time, three times daily. Patients in the treatment group were po administered with Lacidophilin Tablets on the basis of the control group, 2.4 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and serum gastrointestinal hormone levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.50% and 97.50%, respectively, and there was difference between two groups (P<0.05). After treatment, abdominal distension scores, abdominal pain scores, diarrhea scores, constipation scores, and total scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of VIP and MTL in two groups were significantly decreased, but the levels of SP in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Lacidophilin Tablets combined with Trimebutine Maleate Tablets has clinical curative effect in treatment of mixed type of irritable bowel syndrome, can improve clinical symptoms, and regulate serum gastrointestinal hormone levels, which has a certain clinical application value.