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[摘要]
目的 探究健儿止泻颗粒联合蒙脱石散治疗小儿腹泻的临床疗效。方法 选取2015年6月-2017年3月新疆医科大学第一附属医院收治的腹泻患儿102例为研究对象,采取随机数表法将患儿分为对照组和治疗组,每组各51例。对照组口服蒙脱石散,年龄<1岁:1/3袋/次,年龄1~3岁:1/2袋/次,年龄≥ 3岁:1袋/次,3次/d。治疗组在对照组基础上开水冲服健儿止泻颗粒,年龄<1岁:6 g/次,年龄1~5岁:6~12 g/次,年龄≥ 5岁:12~18 g/次,3次/d。两组患儿均连续治疗7 d。观察两组的临床疗效,比较两组的临床症状改善时间和免疫功能指标。结果 治疗后,对照组和治疗组的总有效率分别为92.16%、100.00%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组止泻时间、止吐时间、腹痛改善时间、退热时间、脱水纠正时间均短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、CD4+/CD8+水平均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 健儿止泻颗粒联合蒙脱石散治疗小儿腹泻具有较好的临床疗效,可改善临床症状,调节免疫指标,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical efficacy of Jian'er Zhixie Granules combined with Montmorillonite Powder in treatment of infantile diarrhea. Methods Children (102 cases) with diarrhea in the First Affiliated Hospital of Xinjiang Medical University from June 2015 to March 2017 were randomly divided into control and treatment groups, and each group had 51 cases. Children in the control group were po administered with Montmorillonite Powder, age < 1 year:1/3 bag/time, 1 year ≤ age < 3 years:1/2 bag/time, age ≥ 3 years:1 bag/time, three times daily. Patients in the treatment group were po administered with Jian'er Zhixie Granules on the basis of the control group, age < 1 year:6 g/time, 1 year ≤ age < 5 years:6-12 g/time, age ≥ 3 years:12-18 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the time of symptom improvement and the immune function indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 92.16% and 100.00%, respectively, and there was difference between two groups (P<0.05). After treatment, antidiarrheal time, antiemetic time, the time of abdominal pain improvement, antipyretic time, and dehydration correction time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of IgA, IgG, and CD4+/CD8+ in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jian'er Zhixie Granules combined with Montmorillonite Powder has clinical curative effect in treatment of infantile diarrhea, can improve clinical symptoms, and regulate immune function indexes, with good safety, which has a certain clinical application value.
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