目的 探讨小儿柴桂退热颗粒联合注射用磷酸肌酸钠治疗小儿手足口病的临床疗效。方法 选取2016年1月-2017年1月海安县人民医院收治的小儿手足口病患者64例为研究对象，将所有患儿随机均分为对照组和治疗组，每组各32例。对照组静脉滴注注射用磷酸肌酸钠，1 g加入到5%葡萄糖注射液250 mL中，1次/d。治疗组在对照组的基础上口服小儿柴桂退热颗粒，1岁以内：2.5 g/次，1~3岁：5 g/次，3~6岁：7.5 g/次，3次/d。两组患儿均连续治疗1周。观察两组的临床疗效，比较两组患儿的天冬氨酸氨基转氨酶（AST）、磷酸肌酸激酶同工酶（CK-MB）和超敏C-反应蛋白（hs-CRP）水平。结果 治疗后，对照组和治疗组的总有效率分别为78.1%、96.9%，两组比较差异有统计学意义（P<0.05）。治疗后，两组AST、CK-MB和hs-CRP水平均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小儿柴桂退热颗粒联合注射用磷酸肌酸钠治疗小儿手足口病具有较好的临床疗效，可改善AST、CK-MB和hs-CRP水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Xiao'er Chaigui Tuire Granules combined with Creatine Phosphate Sodium for injection in treatment of hand-foot-mouth disease in children. Methods Children (64 cases) with hand-foot-mouth disease in Hai'an County People's Hospital from January 2016 to January 2017 were randomly divided into control and treatment groups, and each group had 32 cases. Children in the control group were iv administered with Creatine Phosphate Sodium for injection, 1 g added into 5% glucose solution 250 mL, once daily. Children in the treatment group were po administered with Xiao'er Chaigui Tuire Granules on the basis of the control group, age < 1 year:2.5 g/time, 1 year ≤ age < 3 years:5 g/time, 3 year ≤ age < 6 years:7.5 g/time, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and the levels of AST, CK-MB, and hs-CRP in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.1% and 96.9%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of AST, CK-MB, and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiao'er Chaigui Tuire Granules combined with Creatine Phosphate Sodium for injection has clinical curative effect in treatment of hand-foot-mouth disease in children, can improve the levels of AST, CK-MB, and hs-CRP, which has a certain clinical application value.