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[摘要]
目的 探讨固本咳喘胶囊联合吸入用异丙托溴铵溶液治疗慢性支气管炎的临床疗效。方法 选取2015年1月-2016年12月在西电集团医院进行治疗的慢性支气管炎患者100例为研究对象,根据其不同的治疗方法将患者分为对照组(48例)和治疗组(52例)。对照组雾化吸入吸入用异丙托溴铵溶液,2 mL/次,2次/d。治疗组在对照组基础上口服固本咳喘胶囊,3粒/次,3次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的症状评分、血清指标、血气指标和症状消失时间。结果 治疗后,对照组和治疗组的总有效率分别为77.08%、96.15%,两组比较差异有统计学意义(P<0.05)。治疗后,两组咳嗽评分、咳痰评分、气喘评分、总评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组IgA、IgG水平明显升高,TNF-α、IL-6水平明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组pH值、氧分压(pO2)水平明显升高,二氧化碳分压(pCO2)水平明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组喘息、咳嗽、咳痰消失时间均短于对照组,两组比较差异具有统计学意义(P<0.05)。结论 固本咳喘胶囊联合吸入用异丙托溴铵溶液治疗慢性支气管炎具有较好的临床疗效,可明显改善临床症状,降低患者炎性水平,调节患者免疫功能,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Guben Kechuan Capsules combined with Ipratropium Bromide Solution for inhalation in treatment of chronic bronchitis. Methods Patients (100 cases) with chronic bronchitis in Xian XD Group Hospital from January 2015 to December 2016 were enrolled in this study. According to different treatment plans, patients were divided into the control group (48 cases) and the treatment group (52 cases). Patients in the control group were aerosol inhalation administered with Ipratropium Bromide Solution for inhalation, 2 mL/time, twice daily. Patients in the treatment group were po administered with Guben Kechuan Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and symptom scores, serum indexes, blood gas indexes, and symptom disappearance time in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.08% and 96.15%, respectively, and there was difference between two groups (P<0.05). After treatment, cough score, expectoration score, asthma score, and total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the IgA and IgG in two groups were significantly increased, but the levels of TNF-α and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the pH value and pO2 in two groups were significantly increased, but the levels of pCO2 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the disappearance times of wheezing, coughing and expectoration in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Guben Kechuan Capsules combined with Ipratropium Bromide Solution for inhalation has clinical curative effect in treatment of chronic bronchitis, can significantly improve clinical symptom, decrease the inflammatory level, and regulate the immune function, with good safety, which has a certain clinical application value.
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