目的 探讨阿托伐他汀钙片联合小牛血清去蛋白注射液治疗急性脑梗死的临床疗效。方法 选取2016年5月-2017年5月在驻马店市中心医院进行治疗的急性脑梗死患者106例为研究对象，根据用药的差别将所有患者分为对照组和治疗组，每组各53例。对照组静脉滴注小牛血清去蛋白注射液，20 mL加入到5%葡萄糖注射液250 mL中，1次/d。治疗组在对照组基础上睡前口服阿托伐他汀钙片20 mg，1次/d。两组患者均连续治疗2周。观察两组的临床疗效，比较两组的血清学指标、血脂水平、美国国立卫生研究院卒中量表（NIHSS）评分和日常生活能力量表（ADL）评分。结果 治疗后，对照组和治疗组的总有效率分别为81.13%、96.23%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清胶质纤维酸性蛋白（GFAP）、心脏型脂肪酸结合蛋白（H-FABP）、血红素氧合酶1（HO1）水平均显著降低，转化生长因子-β1（TGF-β1）和胰岛素样生长因子1（IGF-1）水平均显著增高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组治疗后总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平均显著降低，高密度脂蛋白胆固醇（HDL-C）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组NIHSS评分明显降低，ADL评分显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 阿托伐他汀钙片联合小牛血清去蛋白注射液治疗急性脑梗死具有较好的临床疗效，可促进神经功能恢复，改善日常生活能力，调节血脂水平和细胞因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Atorvastatin Calcium Tablets combined and Deproteinised Calf Blood Serum Injection in treatment of acute cerebral infarction. Methods Patients (106 cases) with acute cerebral infarction in Zhumadian Central Hospital from June 2016 to May 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 53 cases. Patients in the control group were iv administered with Deproteinised Calf Blood Serum Injection, 20 mL added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Atorvastatin Calcium Tablets at bedtime on the basis of the control group, 20 mg/time, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes, blood lipid levels NIHSS scores, and ADL scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.13% and 96.23%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of GFAP, H-FABP, and HO1 in two groups were significantly decreased, but the levels of TGF-β1 and IGF-1 in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05).After treatment, the levels of TC, TG, and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the NIHSS scores in two groups were significantly decreased, but the ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Atorvastatin calcium combined and Deproteinised Calf Blood Serum Injection has clinical curative effect in treatment of acute cerebral infarction, can promote the recovery of neurological function, improve the ability of daily life, regulate blood lipid levels and cytokines levels, which has a certain clinical application value.