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[摘要]
目的 探究葛根素注射液联合阿替洛尔片治疗急性心肌梗死的临床疗效。方法 选取2014年1月-2016年6月湖北医药学院附属人民医院收治的急性心肌梗死患者98例为研究对象,所有患者随机分为对照组和治疗组,每组各49例。对照组口服阿替洛尔片,6.25~12.5 mg/次(依据心率的快慢调整剂量),2次/d。治疗组在对照组基础上静脉滴注葛根素注射液,300 mg加入到5%葡萄糖注射液500 mL中,1次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组的心功能指标和血清酶学指标。结果 治疗后,对照组和治疗组的总有效率分别为71.43%、91.84%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组左室射血分数(LVEF)、左室短轴缩短率(LVFS)、每搏心输出量(SV)均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 葛根素注射液联合阿替洛尔片治疗急性心肌梗死具有较好的临床疗效,能改善心功能,调节血清CK和CK-MB水平,具有一定临床推广应用价值。
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[Abstract]
Objective To explore the clinical effect of Puerarin Injection combined with Atenolol Tablets in treatment of acute myocardial infarction. Methods Patients (98 cases) with acute myocardial infarction in the Affiliated People's Hospital of Hubei Medical College from January 2014 to June 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Atenolol Tablets, 6.25-12.5 mg/time, twice daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 300 mL added into 5% glucose solution 500 mL, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cardiac function indexes and serum enzyme indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 91.84%, respectively, and there was difference between two groups (P<0.05). After treatment, LVEF, LVFS, and SV in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CK and CK-MB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Puerarin Injection combined with Atenolol Tablets has clinical curative effect in treatment of acute myocardial infarction, can improve cardiac function, regulate the levels of CK and CK-MB, which has a certain clinical application value.
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