目的 探讨甲硝唑联合头孢地尼治疗女性尿路感染的临床疗效。方法 选取江苏省响水县人民医院于2015年11月-2016年11月收治的女性尿路感染患者221例，随机分成对照组（110例）和治疗组（111例）。对照组患者口服头孢地尼分散片，1片/次，3次/d；治疗组在对照组的基础上口服甲硝唑片，1片/次，3次/d。所有患者均治疗2周。评价两组患者临床疗效，同时比较治疗前后两组患者细菌清除率和相关临床体征消失时间。结果 对照组和治疗组总有效率分别为86.36%、98.20%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者细菌清除率达93.75%，明显高于对照组患者的78.79%，两组患者细菌清除率比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者在腰背部疼痛、尿路疼痛以及尿频、尿急消失时间均显著短于对照组患者，两者比较差异具有统计学意义（P<0.05）。结论 头孢地尼联合甲硝唑治疗女性尿路感染具有显著的临床疗效，安全性好，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of metronidazole combined with cefdinir in treatment of female urinary tract infection. Methods Patients (221 cases) with urinary tract infection in Xiangshui People's Hospital from November 2015 to November 2016 were randomly divided into control (110 cases) and treatment (111 cases) groups. Patients in the control group were po administered with Cefdinir Dispersible Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Metronidazole Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the bacterial clearance rate and the disappearance time of clinical signs in two groups before and after treatment were compared. Result After treatment, the clinical efficacy in the control and treatment groups were 86.36% and 98.20%, respectively, and there were differences between two groups (P<0.05). After treatment, the bacterial clearance rate in the treatment group was 93.75%, which was significantly higher than 78.79% in the control groups, and there were differences between two groups (P<0.05). After treatment, the disappearance time of lumbar back pain, urinary tract pain and urinary frequency, urgency in the treatment group significantly lower than that in the control group, and there were differences between two groups (P<0.05). Conclusion Metronidazole combined with cefdinir has significant clinical efficacy in treatment of female urinary tract infection with good safety, which has a certain clinical application value.