目的 探讨肠炎宁胶囊治疗慢性迁延性腹泻的临床疗效。方法 选取2015年9月-2016年11月在齐齐哈尔医学院附属第三医院诊治的慢性迁延性腹泻患者100例，随机分为对照组和治疗组，每组各50例。对照组口服复方黄连素片，4片/次，3次/d。治疗组口服肠炎宁胶囊，5粒/次，3次/d。两组患者均治疗4周。评价两组患者临床疗效，同时比较治疗前后两组患者主要症状体征疗效和止泻时间。结果 对照组患者总有效率和愈显率分别为74.00%和36.00%，均分别显著低于治疗组的92.00%和66.00%，两组总有效率和愈显率比较差异均有统计学意义（P<0.05）。治疗后，治疗组排便次数和粪便性状改善情况均显著优于对照组，两组比较差异具有统计学差异（P<0.05）。治疗后，治疗组患者平均止泻时间显著短于对照组，两组比较差异具有统计学差异（P<0.05）。结论 肠炎宁胶囊可以有效改善慢性迁延性腹泻患者的症状体征，具有一定的临床推广应用价值。

Objective To investigate the efficacy of Changyanning Capsules in treatment of chronic persistent diarrhea. Methods Patients (100 cases) with chronic persistent diarrhea in the Third Affiliated Hospital of Qiqihar Medical Univeisity from September 2015 to November 2016 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Compound Huangliansu Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Changyanning Capsules, 5 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the primary symptoms and signs efficacy, and the average antidiarrheal time in two groups before and after treatment were compared. Results After treatment, clinical efficacy and markedly effective rate in the control group were 74.00% and 36.00%, which were significantly lower than 92.00% and 66.00% in the treatment group, respectively, and there were differences between two groups (P<0.05). After treatment, the improvement of the defecation frequency and fecal property in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). After treatment, the average antidiarrheal time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). Conclusion Changyanning Capsules can effectively improve the symptoms and signs in treatment of chronic persistent diarrhea, which has a certain clinical application value.