目的 探讨小牛血清去蛋白注射液联合奥拉西坦治疗脑挫裂伤的临床疗效。方法 选取深圳市宝安区中心医院2015年8月-2016年8月收治的120例脑挫裂伤患者为研究对象，依据用药差别分为对照组（60例）和治疗组（60例）。对照组静脉滴注奥拉西坦注射液，4.0 g加入到生理盐水250 mL中，1次/d；治疗组在对照组的基础上静脉滴注小牛血清去蛋白注射液，30 mL加入到5%的葡萄糖注射液250 mL中，1次/d。两组患者均连续治疗4周。评价两组患者临床疗效，同时比较治疗前后两组简易智力状态检查量表（MMSE）、格拉斯哥昏迷评分（GCS）和美国国立卫生研究院卒中量表（NIHSS）评分以及血清细胞因子变化。结果 治疗后，对照组和治疗组的总有效率分别为81.67%、96.67%，两组比较差异有统计学意义（P<0.05）。两组MMSE和GCS评分均升高，NIHSS评分降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组的上述评分均优于对照组，两组比较差异有统计学意义（P<0.05）。两组血清白介素-6（IL-6）、肿瘤坏死因子-a（TNF-α）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、髓过氧化物酶（MPO）水平均显著降低（P<0.05）；且治疗后治疗组的上述血清细胞因子均低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小牛血清去蛋白注射液联合奥拉西坦注射液治疗脑挫裂伤疗效显著，有利于降低血清相关细胞因子水平，促进神经功能恢复，具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Deproteinised Calf Blood Serum Injection combined with oxiracetam in treatment of cerebral contusion and laceration. Methods Patients (120 cases) with cerebral contusion and laceration in Shenzhen Baoan District Central Hospital from August 2015 to August 2016 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were iv administered with Oxiracetam Injection, 4.0 g added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Deproteinised Calf Blood Serum Injection, 30 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the MMSE, GCS, NIHSS score, and serum cytokines in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.67% and 96.67%, respectively, and there were differences between two groups (P<0.05). MMSE and GCS score in two groups were significantly increased, but NIHSS score were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). IL-6, TNF-α, GM-CSF, and MPO levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Deproteinised Calf Blood Serum Injection combined with oxiracetam has clinical curative effect in treatment of cerebral contusion and laceration, and can decrease serum cytokine levels and improve neurological function, which has a certain clinical application value.