围手术期镇痛的目的是缓解手术造成的疼痛及其带来的不良反应，防止外周及中枢敏化的发生。近年来，随着医疗行业的飞速发展和众多新型药物的不断出现，常联合不同作用机制的镇痛药物，或不同的镇痛措施，通过多种机制产生镇痛作用，即多模式镇痛以获得更好的镇痛效果，而使药物副作用减到最低。右美托咪定是一种选择性α₂肾上腺素受体激动剂，其镇痛作用已被证实可以作为麻醉剂佐剂应用于临床。可与局部麻醉药或阿片类药物配伍、可应用于静脉注射或应用于各种神经阻滞等方式达到多模式镇痛。对右美托咪定在多模式镇痛中的应用进行综述。

The purpose of perioperative analgesia is to relieve the pain and adverse reactions caused by the operation, and prevent the occurrence of peripheral and central sensitization. In recent years, with the rapid development of medical industry and many new drugs emerging, analgesic drugs combined with different mechanisms, or different measures of analgesia are often used. Analgesic effect by various mechanisms, namely multimodal analgesia is to obtain a better analgesic effect, and the side effects of the drug is reduced to the minimum. Dexmedetomidine is a selective α₂ adrenergic receptor agonist, and its analgesic effect has been shown to be used as an anesthetic adjuvant in clinical practice. It can be compatible with local anesthetics or opioids, and can be used in intravenous injection or in various nerve blocks to achieve multimodal analgesia. The application of dexmedetomidine in multimodal analgesia is summarized in the paper.