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目的 探讨复方斑蝥胶囊联合卡培他滨片治疗晚期结直肠癌的临床疗效。方法 选取2014年1月-2016年12月在南京鼓楼医院集团宿迁市人民医院进行治疗的晚期结直肠癌患者60例为研究对象,入组者依据用药的差别分为对照组和治疗组,每组各30例。对照组口服卡培他滨片,1 250 mg/m2,2次/d,治疗2周,停药1周,3周为1个疗程。治疗组在对照组基础上口服复方斑蝥胶囊,0.75 g/次,2次/d,3周为1个疗程。两组均治疗3个疗程。观察两组的临床疗效,比较两组的肿瘤标志物、生命质量测定量表(QLQ-C30)评分和毒副反应情况。结果 治疗后,对照组和治疗组的有效率(ORR)分别为23.33%、50.00%,临床受益率(CBR)分别为53.33%、86.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清癌胚抗原(CEA)、糖类抗原糖链抗原199(CA199)、糖类抗原糖链抗原242(CA242)水平显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组躯体、认知、情绪、角色和社会功能评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。对照组和治疗组毒副反应发生率分别为66.67%、40.00%,两组比较差异有统计学意义(P<0.05)。结论 复方斑蝥胶囊联合卡培他滨片治疗晚期结直肠癌具有较好的临床疗效,可改善患者生存质量,降低肿瘤标志物水平,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Compound Banmao Capsules combined with Capecitabine Tablets in treatment of advanced colorectal cancer. Methods Patients (60 cases) with advanced colorectal cancer in Suqian People's Hospital of Nanjing Gulou Hospital Group from January 2014 to December 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were po administered with Capecitabine Tablets, 1 250 mg/m2, twice daily, treated for 2 weeks, 3 weeks as a course of treatment. Patients in the treatment group were po administered with Compound Banmao Capsules on the basis of the control group, 0.3 g/time, twice daily, 3 weeks as a course of treatment. Patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and tumor markers, QLQ-C30 scores, toxicity and side effects in two groups were compared. Results After treatment, the clinical efficacies (ORR) in the control and treatment groups were 23.33% and 50.00%, respectively, and the clinical benefit rate (CBR) in the control and treatment groups were 53.33% and 86.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of CEA, CA199, and CA242 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of body, cognition, emotion, role, and social function in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). The incidence rates of toxicity and side effects in the control and treatment groups were 66.67% and 40.00%, respectively, and there was difference between two groups (P<0.05). Conclusion Compound Banmao Capsules combined with Capecitabine Tablets has clinical curative effect in treatment of advanced colorectal cancer, can improve the quality of life, and decrease the level of tumor markers, with good safety, which has a certain clinical application value.
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