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[摘要]
目的 探究四磨汤口服液联合盐酸阿米替林片治疗功能性胃肠病的临床疗效。方法 选取2016年1月-2017年1月在徐州市中心医院消化内科收治的功能性胃肠病患者140例作为研究对象,所有患者随机分为对照组和治疗组,每组各70例。对照组口服盐酸阿米替林片,1片/次,2次/d。治疗组在对照组基础上口服四磨汤口服液,20 mL/次,3次/d。两组患者均连续治疗6周。观察两组的临床疗效,比较两组的消化道症状积分情况。结果 治疗2、4、6周后,对照组总有效率分别为52.86%、62.86%、65.71%,治疗组总有效率分别为61.43%、78.57%、85.71%,两组同期比较差异统计学意义(P<0.05)。治疗2、4、6周后,两组消化道症状积分均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组消化道症状积分明显低于同期对照组,两组比较差异具有统计学意义(P<0.05)。结论 四磨汤口服液联合盐酸阿米替林片治疗功能性胃肠病具有较好的临床疗效,能改善消化道症状,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Simotang Oral Liquid combined with Amitriptyline Hydrochloride Tablets in treatment of functional gastrointestinal disease. Methods Patients (140 cases) with functional gastrointestinal disease in Xuzhou Central Hospital from January 2016 to January 2017 were randomly divided into control and treatment groups, and each group had 70 cases. Patients in the control group were po administered with Amitriptyline Hydrochloride Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Simotang Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and the gastrointestinal symptom scores in two groups were compared. Results After treatment for 2, 4, and 6 weeks, the clinical efficacies in the control group were 52.86%, 62.86%, and 65.71%, respectively, but the clinical efficacies in the treatment group were 61.43%, 78.57%, and 85.71%, respectively, and there was difference at the same time between two groups (P<0.05). After treatment for 2, 4, and 6 weeks, the gastrointestinal symptom scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the gastrointestinal symptom score in the treatment group was significantly lower than those in the control group at the same time, with significant difference between two groups (P<0.05). Conclusion Simotang Oral Liquid combined with Amitriptyline Hydrochloride Tablets has clinical curative effect in treatment of functional gastrointestinal disease, can improve gastrointestinal symptoms, with good safety, which has a certain clinical application value.
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