目的 探讨特布他林联合复方甲氧那明胶囊治疗咳嗽变异性哮喘的临床疗效。方法 选取2016年1月-2017年1月在首都医科大学宣武医院治疗的咳嗽变异性哮喘患者86例，根据治疗方案的差别分为对照组（43例）和治疗组（43例）。对照组患者口服复方甲氧那明胶囊，2粒/次，3次/d。治疗组在对照组基础上雾化吸入硫酸特布他林雾化液，5 mg/次加入生理盐水2 mL，3次/d。两组患者均治疗4周。评价两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、肺功能和血清学指标。结果 治疗后，对照组患者总有效率为79.07%，显著低于治疗组的95.35%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者慢性咳嗽、咳痰、咽痒和喘息急促等临床症状积分均显著降低（P<0.05）；且治疗组临床症状评分比对照组更低（P<0.05）。治疗后，两组患者第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、最大呼气流量（PEF）均显著增高（P<0.05）；且治疗组患者肺功能明显好于对照组（P<0.05）。治疗后，两组患者血清白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）和降钙素原（PET）水平显著降低，白细胞介素-10（IL-10）和干扰素-γ（IFN-γ）水平显著升高，同组比较差异具有统计学意义（P<0.05）；且治疗组上述指标变化明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 特布他林联合复方甲氧那明胶囊治疗咳嗽变异性哮喘不仅能够有效改善临床症状和肺功能，还可改善血清相关炎性因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of terbutaline combined with Compound Methoxyphenamine Capsules in treatment of cough variant asthma. Methods Patients (86 cases) with cough variant asthma in Xuanwu Hospital Capital Medical University from January 2016 to January 2017 were divided into control (43 cases) and treatment (43 cases) groups according to different treatments. Patients in the control group were po administered with Compoumd Methoxyphenamine Hydrochloride Capsules, 2 grains/time, three times daily. Patients in the treatment group were aerosol inhalation administered with Terbutaline Sulphate Solution for nebulization on the basis of the control group, 5 mg added into normal saline 2 mL, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, pulmonary function, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.07%, which was significantly lower than 95.35% in the treatment group, and the difference was statistically significant between two groups (P<0.05). After treatment, the chronic cough, expectoration, pharyngeal itching and shortness of breath scores in two groups was significantly decreased (P<0.05). And the clinical symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the FEV₁, FVC and PEF in two groups were significantly increased (P<0.05). And the pulmonary function in the treatment group was obviously better than that in the control group (P<0.05). After treatment, the IL-4, TNF-α and PET level in two groups was significantly decreased, but IL-10 and IFN-γ level was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the change of these indexes in the treatment group was obviously better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Terbutaline combined with Compound Methoxyphenamine Capsules can effectively improve the clinical symptoms and pulmonary function in treatment of cough variant asthma, and improve serum inflammatory factor levels, which has a certain clinical application value.